P60304.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
8,992 Da
NCBI Official Full Name
Cytotoxin 1
UniProt Protein Name
Cytotoxin 1
UniProt Synonym Protein Names
Cardiotoxin 1; CTX-1; CTX1; Cardiotoxin A1
UniProt Gene Name
CTX A12 PublicationsManual assertion based on opinion iniRef.7 [Similar Products]
UniProt Synonym Gene Names
UniProt Comments for CTX-I
Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation (). It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity and inhibits protein kinases C (PubMed:8448165). It also binds with high affinity to heparin (PubMed:17685633). It also causes skeletal muscle necrosis after intramuscular injection into mice (PubMed:8342169).
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Products associated with CTX-I elisa kit
Pathways associated with CTX-I elisa kit
Organs/Tissues associated with CTX-I elisa kit
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