NP_068772.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homo sapiens forkhead box M1 (FOXM1), transcript variant 2, mRNA
NCBI Official Synonym Full Names
forkhead box M1
NCBI Official Synonym Symbols
MPP2; TGT3; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1B; HFH-11; TRIDENT; MPHOSPH2 [Similar Products]
NCBI Protein Information
forkhead box protein M1; Forkhead, drosophila, homolog-like 16; HNF-3/fork-head homolog 11; M-phase phosphoprotein 2; MPM-2 reactive phosphoprotein 2; forkhead-related protein FKHL16; hepatocyte nuclear factor 3 forkhead homolog 11; transcription factor Trident; winged-helix factor from INS-1 cells
UniProt Protein Name
Forkhead box protein M1
UniProt Synonym Protein Names
Forkhead-related protein FKHL16; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH-11; HNF-3/fork-head homolog 11; M-phase phosphoprotein 2; MPM-2 reactive phosphoprotein 2; Transcription factor Trident; Winged-helix factor from INS-1 cells
UniProt Entry Name
FOXM1_HUMAN
NCBI Summary for FOXM1
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
UniProt Comments for FOXM1
FOXM1: a transcriptional activator factor. Contains 1 fork-head domain. May play a role in the control of cell proliferation. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Phosphorylated in M (mitotic) phase. Three splice variant isoforms have been described. Isoform 1 and isoform 2 appear to be the only activators of gene transcription. Isoform 3, found in rat, does not seem to exist in human.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: nucleoplasm; cytoplasm
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; protein kinase binding; transcription factor activity
Biological Process: regulation of Ras protein signal transduction; transcription from RNA polymerase II promoter; regulation of cell cycle; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA repair; negative regulation of stress-activated MAPK cascade; cell cycle; liver development; regulation of cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; regulation of cell growth; G2/M transition of mitotic cell cycle; vasculogenesis; negative regulation of transcription, DNA-dependent
Research Articles on FOXM1
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Products associated with anti-FOXM1 antibody
Pathways associated with anti-FOXM1 antibody
Diseases associated with anti-FOXM1 antibody
Organs/Tissues associated with anti-FOXM1 antibody
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