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Omega-CNTX-Cs1a recombinant protein :: Omega-ctenitoxin-Cs1a [Recombinant Protein]
Catalog #    MBS1245052
Unit / Price
1 mg (E Coli Derived)  /  $1,055.00 + 1 FREE 8GB USB Flash Drive
1 mg (Yeast Derived)  /  $1,515.00 + 1 FREE 8GB USB Flash Drive
    
 Go to:     Product Names    Product Info    Accession #s    Product Desc    Diseases/Tissues/Pathways    Applications    References 
 Product Name    Omega-ctenitoxin-Cs1a, Recombinant Protein
 Also Known As    Recombinant Cupiennius salei Omega-ctenitoxin-Cs1a
 Product Synonym Names    Recombinant Omega-ctenitoxin-Cs1a; Omega-ctenitoxin-Cs1a; Omega-CNTX-Cs1a; Toxin CSTX-1 Cleaved into the following 2 chains: 1. Toxin CSTX-2a 2. Toxin CSTX-2b
 Product Gene Name    Omega-CNTX-Cs1a recombinant protein [Similar Products]
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 Immunogen Sequence Positions    1-60
 Immunogen Sequence Length    74
 Immunogen Sequence    SCIPKHEECT NDKHNCCRKG LFKLKCQCST FDDESGQPTE RCACGRPMGH QAIETGLNIF
 3D Structure    ModBase 3D Structure for P81694
 Host    E Coli or Yeast
 Purity/Purification    >90%
 Form/Format    This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
 Tag Information    GST tagged
 Species    Cupiennius salei (Wandering spider)
 Storage Buffer    PBS pH 7.4, 50% glycerol
 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 Other Notes for Omega-CNTX-Cs1a recombinant protein    Small volumes of Omega-CNTX-Cs1a recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
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NCBI/Uniprot data below describe general gene information for Omega-CNTX-Cs1a. It may not necessarily be applicable to this product.
 NCBI GI #    6226282 [Other Products]
 NCBI Accession #    P81694.1 [Other Products]
 UniProt Primary Accession #    P81694 [Other Products]
 Molecular Weight    8,361 Da [Similar Products]
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 NCBI Official Full Name    Omega-ctenitoxin-Cs1a
 UniProt Protein Name    Omega-ctenitoxin-Cs1a
 UniProt Synonym Protein Names    Toxin CSTX-1
 UniProt Gene Name    Omega-CNTX-Cs1a [Similar Products]
 UniProt Synonym Gene Names    Omega-CNTX-Cs1a [Similar Products]
 UniProt Entry Name    TXC1_CUPSA
 UniProt Comments for Omega-CNTX-Cs1a    Function: Omega-ctenitoxin-Cs1a blocks mammalian neuronal L-type (Cav1/CACNA1), but no other types of high-voltage-activated Cav channels, and fails to modulate low-voltage-activated Cav channel currents. Using whole-cell patch-clamp experiments on insects (cockroach) Cav, it produces a slow voltage-independent block of both mid/low- and high-voltage-activated insect Cav channels. It causes paralysis in blow flies. At pH 4-6, 80% lethality is shown after 60 min. Potassium ions, histamine, M-ctenitoxin-Cs1a (AC P83619), U1-ctenitoxin-Cs1a (AC P58604), and U1-ctenitoxin-Cs2a (AC P83919) synergistically increase the insecticidal activity of this toxin. Ref.4 Ref.6CSTX-2a and CSTX-2b block voltage-activated calcium channels (Cav)

By similarity. They are less neurotoxic than omega-ctenitoxin-Cs1a on drosophila flies. Ref.4 Ref.6

Subcellular location: Secreted.

Tissue specificity: Expressed by the venom gland. Ref.5

Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin

By similarity.

Toxic dose: LD50 is 10.5 ng/mg on blow flies. Ref.3 Ref.6LD50 is 0.45 pmol on Drosophila. Ref.3 Ref.6

Miscellaneous: Omega-ctenitoxin-Cs1a is the most abundant neurotoxin in the venom of C.salei.

Sequence similarities: Belongs to the spider toxin CSTX superfamily.

Mass spectrometry: Molecular mass is 8352.62 Da from positions 1 - 74. Determined by ESI. Ref.2Molecular mass is 6865.75 Da from positions 1 - 61. Determined by ESI. Ref.2Molecular mass is 6709.57 Da from positions 1 - 60. Determined by ESI. Ref.2
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 UniProt References for Omega-CNTX-Cs1a    • Purification of toxic peptides and the amino acid sequence of CSTX-1 from the multicomponent venom of Cupiennius salei (Araneae:Ctenidae). Kuhn-Nentwig L., Schaller J., Nentwig W.Toxicon 32:287-302(1994) [PubMed: 8016851] [Abstract]Cited for: PROTEIN SEQUENCE, CHARACTERIZATION. Tissue: Venom.
• Amino acid sequence of the toxic spider peptide CSTX-2 and its structural and physiological differences to CSTX-1. Nentwig W., Kuhn-Nentwig L., Schaller J., Kaempfer U.Toxicon 36:1276-1276(1998)Cited for: PROTEIN SEQUENCE OF 1-61, CHARACTERIZATION, MASS SPECTROMETRY.
• A lysine rich C-terminal tail is directly involved in the toxicity of CSTX-1, a neurotoxic peptide from the venom of the spider Cupiennius salei. Kuhn-Nentwig L., Schaller J., Kaempfer U., Imboden H., Malli H., Nentwig W.Arch. Insect Biochem. Physiol. 44:101-111(2000) [PubMed: 10897091] [Abstract]Cited for: PROTEIN SEQUENCE OF 1-61, CHARACTERIZATION, LETHAL DOSE ON BLOW FLY, MASS SPECTROMETRY.
• CSTX-1, a toxin from the venom of the hunting spider Cupiennius salei, is a selective blocker of L-type calcium channels in mammalian neurons. Kubista H., Mafra R.A., Chong Y., Nicholson G.M., Beirao P.S.L., Cruz J.S., Boehm S., Nentwig W., Kuhn-Nentwig L.Neuropharmacology 52:1650-1662(2007) [PubMed: 17517422] [Abstract]Cited for: PARTIAL PROTEIN SEQUENCE, FUNCTION. Tissue: Venom.
• Immunocytochemical localization and secretion process of the toxin CSTX-1 in the venom gland of the wandering spider Cupiennius salei (Araneae: Ctenidae). Malli H., Kuhn-Nentwig L., Imboden H., Moon M.J., Wyler T.Cell Tissue Res. 299:417-426(2000) [PubMed: 10772256] [Abstract]Cited for: TISSUE SPECIFICITY.
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 Searchable Name for Omega-CNTX-Cs1a    anti-Omega-CNTX-Cs1a; Buy Omega-CNTX-Cs1a recombinant protein :: Omega-ctenitoxin-Cs1a, Recombinant Protein (MBS1245052) datasheet at MyBioSource; anti-Omega-CNTX-Cs1a; Omega-CNTX-Cs1a; anti-Omega-ctenitoxin-Cs1a; Recombinant Cupiennius salei Omega-ctenitoxin-Cs1a; Recombinant Omega-ctenitoxin-Cs1a; Omega-ctenitoxin-Cs1a; Omega-CNTX-Cs1a; Toxin CSTX-1 Cleaved into the following 2 chains: 1. Toxin CSTX-2a 2. Toxin CSTX-2b ; Omega-ctenitoxin-Cs1a; Omega-ctenitoxin-Cs1a; Toxin CSTX-1 E Coli or Yeast . (NCBI/UniProt 6226282 P81694.1 P81694 8,361 Da); TXC1_CUPSA; Omega-CNTX-Cs1a recombinant protein; anti-Omega-CNTX-Cs1a
 Precautions    This product is for research use only. Not for use in diagnostic or therapeutic procedures.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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