NP_001158109.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
9,670 Da
NCBI Official Full Name
endonuclease V isoform 2
NCBI Official Synonym Full Names
endonuclease V
NCBI Protein Information
endonuclease V
UniProt Protein Name
Endonuclease V
UniProt Synonym Protein Names
Inosine-specific endoribonuclease
UniProt Synonym Gene Names
UniProt Comments for ENDOV
Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.
Research Articles on ENDOV
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Organs/Tissues associated with ENDOV recombinant protein
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