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| Product Name
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MHC Class I
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| Also Known As
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Mouse Anti MHC Class I (H-2K)
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| Product Synonym Names
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MHC Class I, H-2K Antibody; MHC Class I, (H-2K) Mouse Antibody;
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| Product Gene Name
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MHC Class I
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[Similar Products]
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 TOP
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| Immunogen Sequence Length
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236
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TOP
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| Clonality
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Monoclonal
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| Isotype
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Mouse IgG2b
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| Clone Number
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NYRmH-2K
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| Host
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Mouse
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| Specificity
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Recognizes most mouse H-2K haplotypes (k,p,q,r,s). Does NOT react with H-2kd.
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| Purity/Purification
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Ion Exchange Column
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| Form/Format
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1mg/ml in PBS (after reconstitution).
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| Immunogen
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Purified mouse LN cells (C57Bl/6 anti-BALB/c).
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| Antibody Properties
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Cytotoxic and staining antibody. For staining, use 10 ml/106 cells. Titer for cytotoxicity should be determined by the investigator.
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| Reconstitution
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Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Stability / Shelf LifeTwo years lyophilized, one month in solution at 4 degree C.
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| Preparation and Storage
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Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
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| Other Notes
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Small volumes of MHC Class I antibody may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
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TOP
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| NCBI GI #
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4200191
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[Other Products]
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TOP
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| Product Description specifically for MHC Class I antibody
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MHC Class I is a membrane spanning molecule consisting of 2 proteins. MHC Class I is just about 350 amino acids in length, with roughly 75 amino acids at the carboxylic end comprising the transmembrane and cytoplasmic portions. The remaining 270 amino acids, are divided into three globular domains labeled Alpha-1, Alpha-2 and Alpha-3 prime, with Alpha-1 being closest to the amino terminus and Alpha-3 closest to the membrane. The second portion of the molecule is a small globular protein called Beta-2 Microglobulin It links primarily with the Alpha-3 prime domain and is essential for MHC stability. The MHC ability to show a vast range of antigenic peptides for T cell recognition needs a compromise between broad specificity and high affinity. Both MHC class I and MHC class II show an exceptional structure while the peptide main chain is tightly bound and peptide side chains show less restrictive interactions. It is primarily the peptide side-chain contacts and conformational variability that ensures that the peptide-MHC complex presents an antigenically unique surface to T cell receptors.
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| Searchable Name
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Buy MHC Class I antibody :: MHC Class I, Monoclonal Antibody (MBS140072) datasheet at MyBioSource; anti-MHC Class I; MHC Class I; anti-MHC Class I; Mouse Anti MHC Class I (H-2K); MHC Class I, H-2K Antibody; MHC Class I, (H-2K) Mouse Antibody; ; MHC class I [Gadus morhua] Mouse . (NCBI/UniProt4200191); Mouse IgG2b; NYRmH-2K
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| Precautions
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This product is for research use only. Not for use in diagnostic or therapeutic procedures.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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