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HP native protein :: Haptoglobin [Native Protein]
Catalog #    MBS143109
Unit / Price
0.2 mg  /  $180.00 + 1 FREE 8GB USB Flash Drive
1 mg  /  $265.00 + 1 FREE 8GB USB Flash Drive
10 mg  /  $1,740.00 + 2 FREE 8GB USB Flash Drive
    
 Go to:     Product Names    Product Info    Accession #s    Product Desc    Diseases/Tissues/Pathways    Applications    References 
 Product Name    Haptoglobin, Native Protein
 Also Known As    Human Haptoglobin
 Product Synonym Names    Haptoglobin Human; Haptoglobin; HP; BP; HPA1S; MGC111141; HP2-ALPHA-2.
 Product Gene Name    HP native protein [Similar Products]
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 Immunogen Sequence Length    347
 Chromosome Location    Chromosome: 16; NC_000016.9 (72088508..72094955). Location: 16q22.2
 OMIM    140100
 3D Structure    ModBase 3D Structure for P00738
 Host    Pooled human plasma
 Purity/Purification    Greater than 96.0%.
 Form/Format    Lyophilized from 0.02M NH4HCO3. May contain traces of buffer salts.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
 Preparation and Storage    Human HDL although stable at 4 degree C for 1 week, should be stored below -15 degree C (short term i.e. < 3 months) and below -70 degree C for long term.
 Other Notes for HP native protein    Small volumes of HP native protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
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 Product Description specifically for HP native protein    Human Haptoglobin produced from pooled human plasma corresponding to the Mw of isotypes of Haptoglobin at 86kD and >200kD.

Introduction: Haptoglobin is a glycoprotein which is synthesized in the liver and circulates in the blood. Haptoglobin is produced typically by hepatocytes but also by other tissues: e.g. skin, lung, and kidney. It is a positive acute phase protein that binds free hemoglobin and removes it from the circulation to prevent kidney injury, and iron loss following hemolysis. The haptoglobin-hemoglobin complex is subsequently removed by the reticuloendothelial system (generally the spleen). As the reticuloendothelial system removes the haptoglobin-hemoglobin complex from the body, haptoglobin levels are reduced in hemolytic anaemias. In the course of binding hemoglobin, haptoglobin sequesters the iron inside hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis. Haptoglobin consists of two a- and two b-chains, connected by disulfide bonds. Three major haptoglobin phenotypes are known to exist (Hp 1-1, Hp 2-1, and Hp 2-2). Hp 1-1 is biologically the most effective in binding free hemoglobin and suppressing inflammatory responses associated with free hemoglobin. Hp 2-2 is biologically the least active, and Hp 2-1 is moderately active. Haptoglobin's molecular mass ranges from 8-200 kDa.Reduced levels can be seen in haemolysis and impaired liver function. High levels are a marker for acute or chronic inflammation. Ahaptoglobinemia or hypohaptoglobinemia are caused by mutations in the haptoglobin gene and/or its regulatory regions. Haptoglobin is also linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria.
 Product Categories/Family for HP native protein    RECOMBINANT & NATURAL PROTEINS (Natural Proteins)
NCBI/Uniprot data below describe general gene information for HP. It may not necessarily be applicable to this product.
 NCBI GI #    186910296 [Other Products]
 NCBI GeneID    3240 [Other Products]
 NCBI Accession #    NP_001119574.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001126102.1 [Other Products]
 UniProt Primary Accession #    P00738 [Other Products]
 UniProt Secondary Accession #    P00737; Q0VAC4; Q2PP15; Q3B7J0; Q6LBY9; Q9UC67; B0AZL5 [Other Products]
 UniProt Related Accession #    P00738 [Other Products]
 Molecular Weight    45,205 Da [Similar Products]
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 NCBI Official Full Name    haptoglobin isoform 2 preproprotein
 NCBI Official Synonym Full Names    haptoglobin
 NCBI Official Symbol    HP [Similar Products]
 NCBI Official Synonym Symbols    BP; HPA1S; HP2ALPHA2 [Similar Products]
 NCBI Protein Information    haptoglobin; zonulin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide
 UniProt Protein Name    Haptoglobin
 UniProt Synonym Protein Names    Zonulin
 UniProt Gene Name    HP [Similar Products]
 UniProt Entry Name    HPT_HUMAN
 NCBI Summary for HP    This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
 UniProt Comments for HP    Function: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Ref.27Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. Ref.27

Subunit structure: Tetramer of two alpha and two beta chains; disufide-linked. The Hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers. Interacts with CD163.

Subcellular location: Secreted.

Tissue specificity: Expressed by the liver and secreted in plasma.

Polymorphism: In the human populations there are two major allelic forms, alpha-1 (1-1) with 83 residues and alpha-2 (2-2) with 142 residues. These alleles determine 3 possible genotypes, homozygous (1-1 or 2-2) and heterozygous (2-1), and 3 major phenotypes HP*1F/HP*1S and HP*2FS. The two main alleles of HP*1 are called HP*1F (fast) and HP*1S (slow). The alleles exhibit different oligomerization properties. In healthy males, but not in females, the Hp 2-2 phenotype is associated with higher serum iron, decreased Antimicrobial; Antioxidant capability, and less efficient clearance from the circulation, than Hp 1-1 and 2-1.

Involvement in disease: Anhaptoglobinemia (AHP) [MIM:614081]: A condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Congenital haptoglobin deficiency is a risk factor for anaphylactic non-hemolytic transfusion reactions.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.28

Sequence similarities: Belongs to the peptidase S1 family.Contains 1 peptidase S1 domain.Contains 2 Sushi (CCP/SCR) domains.

Caution: Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.
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 NCBI References for HP    1. Increased plasma zonulin in patients with sepsis.
2. Haptoglobin genotype is a consistent marker of coronary heart disease risk among individuals with elevated glycosylated hemoglobin.
3. Inflammatory markers and haptoglobin polymorphism in Saudi with non-insulin-dependent diabetes mellitus.
4. Pulmonary haptoglobin (pHp) is part of the surfactant system in the human lung.
5. Erythropoietin, ferritin, haptoglobin, hemoglobin and transferrin receptor in metabolic syndrome: a case control study.
 UniProt References for HP    • Molecular cloning of human haptoglobin cDNA: evidence for a single mRNA coding for alpha 2 and beta chains. van der Straten A., Herzog A., Jacobs P., Cabezon T., Bollen A.EMBO J. 2:1003-1007(1983) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• Identification and characterization of human haptoglobin cDNA. Yang F., Brune J.L., Baldwin W.D., Barnett D.R., Bowman B.H.Proc. Natl. Acad. Sci. U.S.A. 80:5875-5879(1983) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• Characterization of human haptoglobin cDNAs coding for alpha 2FS beta and alpha 1S beta variants. van der Straten A., Herzog A., Cabezon T., Bollen A.FEBS Lett. 168:103-107(1984) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS 29-ALA--GLU-87 DEL; ASP-129 AND LYS-130. Tissue: Liver.
• Evolution of haptoglobin: comparison of complementary DNA encoding Hp alpha 1S and Hp alpha 2FS. Brune J.L., Yang F., Barnett D.R., Bowman B.H.Nucleic Acids Res. 12:4531-4538(1984) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT 29-ALA--GLU-87 DEL.
• Structure and expression of the human haptoglobin locus. Bensi G., Raugei G., Klefenz H., Cortese R.EMBO J. 4:119-126(1985) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-129.
 Research Articles on HP    1. study of effect of occupational exposure to lead in metallurgy workers in Poland on blood levels of transferrin (TRF), ceruloplasmin (CER) and haptoglobin (HPG): Significant increase in haptoglobin level was observed only in low lead exposure group.
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 Searchable Name for HP    anti-HP; Buy HP native protein :: Haptoglobin, Native Protein (MBS143109) datasheet at MyBioSource; anti-HP; BP; HPA1S; HP2ALPHA2; anti-Haptoglobin; Human Haptoglobin; Haptoglobin Human; Haptoglobin; HP; BP; HPA1S; MGC111141; HP2-ALPHA-2.; haptoglobin isoform 2 preproprotein; haptoglobin; Haptoglobin; Zonulin Pooled human plasma . (NCBI/UniProt 186910296 NP_001119574.1 P00738 NM_001126102.1 P00738 P00737; Q0VAC4; Q2PP15; Q3B7J0; Q6LBY9; Q9UC67; B0AZL5 45,205 Da); RECOMBINANT & NATURAL PROTEINS (Natural Proteins); Chromosome: 16; NC_000016.9 (72088508..72094955). Location: 16q22.2; 3240; HPT_HUMAN; HP native protein; anti-HP
 Precautions    This product is for research use only. Not for use in diagnostic or therapeutic procedures.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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Products associated with HP native proteinPathways associated with HP native protein
 Product Name  Ref Prod  PubMed Publications
 HP native protein  CD163 native protein  >51 publications with HP and CD163
 HP native protein  ITGAM native protein  >10 publications with HP and ITGAM
 HP native protein  ITGB2 native protein  >8 publications with HP and ITGB2
 HP native protein  CD22 native protein  >5 publications with HP and CD22
 HP native protein  HBB native protein  >4 publications with HP and HBB
 HP native protein  ADAMTS4 native protein  >1 publications with HP and ADAMTS4
 Product Name  Products by Pathway  Pathway Diagram
 HP native protein  Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 HP native protein  Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram
 HP native protein  Amb2 Integrin Signaling Pathway antibodies  Amb2 Integrin Signaling Pathway Diagram
Diseases associated with HP native proteinOrgans/Tissues associated with HP native protein
 Disease Name  Ref Prod  Pubmed Publications
 Cardiovascular Diseases Antibodies  anti-HP  >1350 publications with HP and Cardiovascular Diseases
 Inflammation Antibodies  anti-HP  >906 publications with HP and Inflammation
 Heart Diseases Antibodies  anti-HP  >601 publications with HP and Heart Diseases
 Hypersensitivity Antibodies  anti-HP  >579 publications with HP and Hypersensitivity
 Liver Diseases Antibodies  anti-HP  >478 publications with HP and Liver Diseases
 Kidney Diseases Antibodies  anti-HP  >400 publications with HP and Kidney Diseases
 Drug Toxicity Antibodies  anti-HP  >386 publications with HP and Drug Toxicity
 Necrosis Antibodies  anti-HP  >380 publications with HP and Necrosis
 Hypertension Antibodies  anti-HP  >369 publications with HP and Hypertension
 Fibrosis Antibodies  anti-HP  >364 publications with HP and Fibrosis
 Organ/Tissue Name  Ref Prod  Pubmed Publications
 Blood Antibodies  HP antibody  >4814 publications with HP and Blood
 Stomach Antibodies  HP antibody  >1215 publications with HP and Stomach
 Liver Antibodies  HP antibody  >1013 publications with HP and Liver
 Lung Antibodies  HP antibody  >921 publications with HP and Lung
 Muscle Antibodies  HP antibody  >616 publications with HP and Muscle
 Ovary Antibodies  HP antibody  >128 publications with HP and Ovary
 Testis Antibodies  HP antibody  >47 publications with HP and Testis
 Uncharacterized Tissue Antibodies  HP antibody  >1 publications with HP and Uncharacterized Tissue
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