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HP native protein :: Haptoglobin Native Protein

Catalog #    MBS143109 HP native protein
Unit / Price
0.2 mg  /  $180 +1 FREE 8GB USB
1 mg  /  $265 +1 FREE 8GB USB
10 mg  /  $1,615 +2 FREE 8GB USB
 Go to:     Product Names    Product Info    Accession #s    Product Desc    Diseases/Tissues/Pathways    Applications    References 
 Product Name   

Haptoglobin (HP), Native Protein

 Also Known As   

Human Haptoglobin

 Product Synonym Names    Haptoglobin Human; Haptoglobin Human; Haptoglobin; HP; BP; HPA1S; MGC111141; HP2-ALPHA-2; Haptoglobin
 Product Gene Name   

HP native protein

[Similar Products]
 OMIM    140100
 3D Structure    ModBase 3D Structure for P00738
 Host    Pooled human plasma
 Purity/Purification    Greater than 95.0%.
 Form/Format    The MMP-3 (0.30mg/ml) is supplied as a 0.2um filtered solution in Tris, NaCl and Brij35.
Physical Appearance: Sterile Filtered colorless solution.
 Concentration    0.30mg/ml (lot specific)
 Solubility    It is recommended to reconstitute the lyophilized Haptoglobin in sterile water not less than 100ug/ml, which can then be further diluted to otehr aqueous solutions.
 Preparation and Storage    Human Haptoglobin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL18 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
 Other Notes for HP native protein    Small volumes of HP native protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
 Searchable Terms for HP    anti-HP; Buy HP native protein, Haptoglobin Native Protein (MBS143109) product datasheet at MyBioSource, Native Proteins; RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Haptoglobin; 3240; HPT_HUMAN; HP native protein; anti-HP. N/A

Product Description specifically for HP native protein

   Description: Human Haptoglobin produced from pooled human plasma corresponding to the Mw of isotypes of Haptoglobin at 86kD and >200kD.

Introduction: Haptoglobin is a glycoprotein which is synthesized in the liver and circulates in the blood. Haptoglobin is produced typically by hepatocytes but also by other tissues: e.g. skin, lung, and kidney. It is a positive acute phase protein that binds free hemoglobin and removes it from the circulation to prevent kidney injury, and iron loss following hemolysis. The haptoglobin-hemoglobin complex is subsequently removed by the reticuloendothelial system (generally the spleen). As the reticuloendothelial system removes the haptoglobin-hemoglobin complex from the body, haptoglobin levels are reduced in hemolytic anaemias. In the course of binding hemoglobin, haptoglobin sequesters the iron inside hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis. Haptoglobin consists of two a- and two b-chains, connected by disulfide bonds. Three major haptoglobin phenotypes are known to exist (Hp 1-1, Hp 2-1, and Hp 2-2). Hp 1-1 is biologically the most effective in binding free hemoglobin and suppressing inflammatory responses associated with free hemoglobin. Hp 2-2 is biologically the least active, and Hp 2-1 is moderately active. Haptoglobin's molecular mass ranges from 8-200 kDa.Reduced levels can be seen in haemolysis and impaired liver function. High levels are a marker for acute or chronic inflammation. Ahaptoglobinemia or hypohaptoglobinemia are caused by mutations in the haptoglobin gene and/or its regulatory regions. Haptoglobin is also linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria.
 Product Categories/Family for HP native protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Haptoglobin
NCBI/Uniprot data below describe general gene information for HP. It may not necessarily be applicable to this product.
 NCBI GI #    186910296 [Other Products]
 NCBI GeneID    3240 [Other Products]
 NCBI Accession #    NP_001119574.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001126102.1 [Other Products]
 UniProt Primary Accession #    P00738 [Other Products]
 UniProt Secondary Accession #    P00737; Q0VAC4; Q0VAC5; Q2PP15; Q3B7J0; Q6LBY9; Q9UC67; B0AZL5 [Other Products]
 UniProt Related Accession #    P00738 [Other Products]
 NCBI Official Full Name    haptoglobin isoform 2 preproprotein
 NCBI Official Synonym Full Names    haptoglobin
 NCBI Official Symbol    HP [Similar Products]
 NCBI Official Synonym Symbols   


[Similar Products]
 NCBI Protein Information    haptoglobin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; zonulin
 UniProt Protein Name    Haptoglobin
 UniProt Synonym Protein Names   

ZonulinCleaved into the following 2 chains:Haptoglobin alpha chain; Haptoglobin beta chain

 UniProt Gene Name    HP [Similar Products]
 UniProt Entry Name    HPT_HUMAN
 NCBI Summary for HP    This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
 UniProt Comments for HP    HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q22.2

Cellular Component: extracellular space; extracellular region

Molecular Function: antioxidant activity; protein binding; hemoglobin binding; catalytic activity

Biological Process: receptor-mediated endocytosis; response to hydrogen peroxide; immune system process; metabolic process; defense response to bacterium; negative regulation of oxidoreductase activity; acute-phase response; defense response

Disease: Anhaptoglobinemia
 UniProt References for HP    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland. NHLBI resequencing and genotyping service (RS&G) Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
2. "The sequence and analysis of duplication-rich human chromosome 16."Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELES HP*1F AND HP*1S). Tissue: Liver. "Expression of cloned human haptoglobin and alpha 1-antitrypsin complementary DNAs in Saccharomyces cerevisiae."van der Straten A., Falque J.-C., Loriau R., Bollen A., Cabezon T.DNA 5:129-136(1986) [PubMed] [Europe PMC] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-19. "Sequence of human haptoglobin cDNA: evidence that the alpha and beta subunits are coded by the same mRNA."Raugei G., Bensi G., Colantuoni V., Romano V., Santoro C., Costanzo F., Cortese R.Nucleic Acids Res. 11:5811-5819(1983) [PubMed] [Europe PMC] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-406.
4. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D.Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 3-406. "Duplication within the haptoglobin Hp2 gene."Maeda N., Yang F., Barnett D.R., Bowman B.H., Smithies O.Nature 309:131-135(1984) [PubMed] [Europe PMC] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-375. "Covalent structure of human haptoglobin: a serine protease homolog."Kurosky A., Barnett D.R., Lee T.-H., Touchstone B., Hay R.E., Arnott M.S., Bowman B.H., Fitch W.M.Proc. Natl. Acad. Sci. U.S.A. 77:3388-3392(1980) [PubMed] [Europe PMC] [Abstract]. Cited for: PROTEIN SEQUENCE OF 19-28; 88-160 AND 162-406, DISULFIDE BONDS. "Protein analysis of human maculae in relation to age-related maculopathy."Kliffen M., de Jong P.T.V.M., Luider T.M.Lab. Invest. 73:267-272(1995) [PubMed] [Europe PMC] [Abstract]. Cited for: PROTEIN SEQUENCE OF 162-176. Tissue: Eye. "Studies on the interchain disulfides of human haptoglobins."Malchy B., Dixon G.H.Can. J. Biochem. 51:249-264(1973) [PubMed] [Europe PMC] [Abstract]. Cited for: DISULFIDE BONDS. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Zhang H., Li X.-J., Martin D.B., Aebersold R.Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]. Cited for: GLYCOSYLATION AT ASN-207 AND ASN-241. Tissue: Plasma and Serum.
5. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]. Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-184; ASN-207; ASN-211 AND ASN-241. Tissue: Plasma.
 Research Articles on HP    1. Serum zonulin is increased in polycystic ovary syndrome and correlates with insulin resistance and severity of anovulation.
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HP native proteinPathways associated with HP native protein
 Reference Product  PubMed Publications
 CD163 native protein  >60 publications with HP and CD163
 APOE native protein  >30 publications with HP and APOE
 IL6 native protein  >28 publications with HP and IL6
 HBA1 native protein  >26 publications with HP and HBA1
 APOA1 native protein  >13 publications with HP and APOA1
 HBB native protein  >4 publications with HP and HBB
 MIS12 native protein  >2 publications with HP and MIS12
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram
 Amb2 Integrin Signaling Pathway antibodies  Amb2 Integrin Signaling Pathway Diagram
Diseases associated with HP native proteinOrgans/Tissues associated with HP native protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1612 publications with HP and Cardiovascular Diseases
 Inflammation Antibodies  >1117 publications with HP and Inflammation
 Hypersensitivity Antibodies  >648 publications with HP and Hypersensitivity
 Liver Diseases Antibodies  >593 publications with HP and Liver Diseases
 Disease Models, Animal Antibodies  >530 publications with HP and Disease Models, Animal
 Hypertension Antibodies  >483 publications with HP and Hypertension
 Kidney Diseases Antibodies  >470 publications with HP and Kidney Diseases
 Autoimmune Diseases Antibodies  >466 publications with HP and Autoimmune Diseases
 Necrosis Antibodies  >458 publications with HP and Necrosis
 Fibrosis Antibodies  >441 publications with HP and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5508 publications with HP and Blood
 Brain Antibodies  >1271 publications with HP and Brain
 Liver Antibodies  >1213 publications with HP and Liver
 Lung Antibodies  >1137 publications with HP and Lung
 Muscle Antibodies  >728 publications with HP and Muscle
 Kidney Antibodies  >681 publications with HP and Kidney
 Connective Tissue Antibodies  >327 publications with HP and Connective Tissue
 Bone Marrow Antibodies  >222 publications with HP and Bone Marrow
 Adipose Tissue Antibodies  >175 publications with HP and Adipose Tissue
 Ovary Antibodies  >146 publications with HP and Ovary
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