NP_001296
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
claudin-4
NCBI Official Synonym Full Names
claudin 4
NCBI Official Synonym Symbols
CPER; CPE-R; CPETR; CPETR1; WBSCR8; hCPE-R [Similar Products]
NCBI Protein Information
claudin-4; CPE-receptor; Clostridium perfringens enterotoxin receptor 1; Williams-Beuren syndrome chromosomal region 8 protein
UniProt Protein Name
Claudin-4
UniProt Synonym Protein Names
Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein
UniProt Synonym Gene Names
UniProt Entry Name
CLD4_HUMAN
NCBI Summary for CLDN4
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]
UniProt Comments for CLDN4
Claudin-4: Plays a major role in tight junction-specific obliteration of the intercellular space. CLDN4 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the claudin family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Cytoskeletal
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: tight junction; apicolateral plasma membrane; integral to plasma membrane; apical plasma membrane; basal plasma membrane; plasma membrane; lateral plasma membrane
Molecular Function: identical protein binding; transmembrane receptor activity; structural molecule activity
Biological Process: female pregnancy; signal transduction; response to progesterone stimulus; calcium-independent cell-cell adhesion
Research Articles on CLDN4
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Products associated with anti-CLDN4 antibody
Pathways associated with anti-CLDN4 antibody
Diseases associated with anti-CLDN4 antibody
Organs/Tissues associated with anti-CLDN4 antibody
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