NP_065139.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,683 Da
NCBI Official Full Name
CD177 antigen
NCBI Official Synonym Full Names
CD177 molecule
NCBI Official Synonym Symbols
NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP [Similar Products]
NCBI Protein Information
CD177 antigen; NB1 glycoprotein; cell surface receptor; human neutrophil alloantigen 2a; polycythemia rubra vera protein 1
UniProt Protein Name
CD177 antigen
UniProt Synonym Protein Names
Human neutrophil alloantigen 2a; HNA-2a; NB1 glycoprotein; NB1 GP; Polycythemia rubra vera protein 1; PRV-1; CD_antigen: CD177
UniProt Synonym Gene Names
UniProt Entry Name
CD177_HUMAN
NCBI Summary for CD177
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]
UniProt Comments for CD177
CD177: Induced by CSF3 in resting granulocytes. Induced in patients with polycythemia vera (PV) and with essential thrombocythemia (ET). 3 isoforms of the human protein are produced by alternative splicing
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: plasma membrane
Biological Process: blood coagulation; leukocyte migration
Research Articles on CD177
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Products associated with anti-CD177 antibody
Pathways associated with anti-CD177 antibody
Diseases associated with anti-CD177 antibody
Organs/Tissues associated with anti-CD177 antibody
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