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XK antibody :: KX / XK [Polyclonal Antibody]
Catalog #    MBS241098
Unit / Price
0.05 mg  /  $470.00 + 1 FREE 8GB USB Flash Drive
    
 Go to:     Product Names    Product Info    Accession #s    Product Desc    Diseases/Tissues/Pathways    Applications    References 
 Product Name    KX / XK, Antibody
 Also Known As    Rabbit anti-Human XK Polyclonal Antibody
 Product Synonym Names    KX / XK Rabbit anti-Human Polyclonal (aa409-425) Antibody
 Product Gene Name    XK antibody [Similar Products]
 Product Synonym Gene Name    XK; KX; Membrane transport protein xk; X1k; XKR1 [Similar Products]
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 Immunogen Sequence Positions    409-425
 Immunogen Sequence Length    444
 Chromosome Location    Chromosome: X; NC_000023.10 (37545133..37591383). Location: Xp21.1
 OMIM    300842
 3D Structure    ModBase 3D Structure for P51811
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
 Specificity    Amino acids 409 to 425 of human XK
 Purity/Purification    Protein G Column
 Form/Format    PBS, 0.09% sodium azide.
 Concentration    1 mg/ml (lot specific)
 Immunogen Description    Synthetic peptide from human XK.
 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes for XK antibody    Small volumes of XK antibody may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
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 Product Categories/Family for XK antibody    Family: Transporter; Subfamily: KX Blood-group Antigen
 Applications Tested/Suitable for XK antibody    ELISA (EIA), Immunohistochemistry (IHC/Paraffin)
 Application Notes for XK antibody    ELISA (1:000 - 1:1000), IHC-P (10 ug/ml)
 Immunohistochemistry (IHC) #1 for XK antibody    Anti-XK antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
XK antibody Immunohistochemistry (IHC) #1 (IHC) image
 Immunohistochemistry (IHC) #2 for XK antibody    Anti-XK antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
XK antibody Immunohistochemistry (IHC) #2 (IHC) image
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NCBI/Uniprot data below describe general gene information for XK. It may not necessarily be applicable to this product.
 NCBI GI #    10835267 [Other Products]
 NCBI GeneID    7504 [Other Products]
 NCBI Accession #    NP_066569.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021083.2 [Other Products]
 UniProt Primary Accession #    P51811 [Other Products]
 UniProt Secondary Accession #    Q4TTN6; Q8IUK6; Q9UC77 [Other Products]
 UniProt Related Accession #    P51811 [Other Products]
 Molecular Weight    50,902 Da
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 NCBI Official Full Name    membrane transport protein XK
 NCBI Official Synonym Full Names    X-linked Kx blood group (McLeod syndrome)
 NCBI Official Symbol    XK [Similar Products]
 NCBI Official Synonym Symbols    KX; X1k; XKR1; MCLDS [Similar Products]
 NCBI Protein Information    membrane transport protein XK; Kx antigen; XK-related protein 1; kell complex 37 kDa component; Kell blood group precursor (McLeod phenotype); XK, Kell blood group complex subunit (McLeod syndrome)
 UniProt Protein Name    Membrane transport protein XK
 UniProt Synonym Protein Names    Kell complex 37 kDa component; Kx antigen; XK-related protein 1
 UniProt Gene Name    XK [Similar Products]
 UniProt Synonym Gene Names    XKR1; XRG1 [Similar Products]
 UniProt Entry Name    XK_HUMAN
 NCBI Summary for XK    This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. [provided by RefSeq, Jul 2008]
 UniProt Comments for XK    Function: May be involved in sodium-dependent transport of neutral amino acids or oligopeptides.

Subunit structure: Heterodimer with Kell; disulfide-linked. Ref.7

Subcellular location: Membrane; Multi-pass membrane protein

Potential.

Tissue specificity: High levels in skeletal muscle, heart, brain, and pancreas; low levels in placenta, lung, liver, and kidney.

Post-translational modification: Not glycosylated. Ref.6

Polymorphism: XK is responsible for the Kx blood group system.

Involvement in disease: Defects in XK are the cause of McLeod syndrome (MLS) [

MIM:300842]. It is an X-linked multisystem disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems. Ref.8 Ref.9 Ref.10

Sequence similarities: Belongs to the XK family.
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 NCBI References for XK    1. Two McLeod patients with novel mutations in XK.
2. Comprehensive analysis of the genes responsible for neuroacanthocytosis in mood disorder and schizophrenia.
3. McLeod Neuroacanthocytosis Syndrome
4. Ubiquitin-mediated proteolysis of HuR by heat shock.
5. Phenotypic variability of a distinct deletion in McLeod syndrome.
 UniProt References for XK    • Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein. Ho M., Chelly J., Carter N., Danek A., Crocker P., Monaco A.P.Cell 77:869-880(1994) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2]Ho M.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databasesCited for: SEQUENCE REVISION TO 204-205.
• A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates. Huang C.-H., Chen Y.Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. [4]SeattleSNPs variation discovery resourceSubmitted (MAY-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
 Research Articles on XK    1. Novel XK protein mutations are reported in two patients who exhibit typical clinical characteristics of McLeod syndrome.
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 Searchable Name for XK    anti-XK; Buy XK antibody :: KX / XK, Polyclonal Antibody (MBS241098) datasheet at MyBioSource; anti-XK; XK; KX; Membrane transport protein xk; X1k; XKR1; KX; X1k; XKR1; MCLDS; XKR1; XRG1; anti-KX / XK; Rabbit anti-Human XK Polyclonal Antibody; KX / XK Rabbit anti-Human Polyclonal (aa409-425) Antibody; membrane transport protein XK; X-linked Kx blood group (McLeod syndrome); Membrane transport protein XK; Kell complex 37 kDa component; Kx antigen; XK-related protein 1 Rabbit anti-Human. (Tested application: ELISA (EIA), Immunohistochemistry (IHC/Paraffin)) (NCBI/UniProt 10835267 NP_066569.1 P51811 NM_021083.2 P51811 Q4TTN6; Q8IUK6; Q9UC77 50,902 Da); Family: Transporter; Subfamily: KX Blood-group Antigen; Chromosome: X; NC_000023.10 (37545133..37591383). Location: Xp21.1; 7504; XK_HUMAN; XK antibody; anti-XK
 Precautions    This product is for research use only. Not for use in diagnostic or therapeutic procedures.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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Products associated with XK antibodyDiseases associated with XK antibody
 Product Name  Ref Prod  PubMed Publications
 XK antibody  KEL antibody  >8 publications with XK and KEL
 Disease Name  Ref Prod  Pubmed Publications
 Hematologic Diseases Antibodies  anti-XK  >27 publications with XK and Hematologic Diseases
 Chorea Antibodies  anti-XK  >26 publications with XK and Chorea
 Genetic Diseases, Inborn Antibodies  anti-XK  >23 publications with XK and Genetic Diseases, Inborn
 Neoplasms Antibodies  anti-XK  >23 publications with XK and Neoplasms
 Neuromuscular Diseases Antibodies  anti-XK  >21 publications with XK and Neuromuscular Diseases
 Congenital Abnormalities Antibodies  anti-XK  >17 publications with XK and Congenital Abnormalities
 Muscular Diseases Antibodies  anti-XK  >13 publications with XK and Muscular Diseases
 Anemia Antibodies  anti-XK  >9 publications with XK and Anemia
 Drug Toxicity Antibodies  anti-XK  >8 publications with XK and Drug Toxicity
 Vascular Diseases Antibodies  anti-XK  >8 publications with XK and Vascular Diseases
Organs/Tissues associated with XK antibody
 Organ/Tissue Name  Ref Prod  Pubmed Publications
 Blood Antibodies  XK antibody  >98 publications with XK and Blood
 Brain Antibodies  XK antibody  >31 publications with XK and Brain
 Muscle Antibodies  XK antibody  >23 publications with XK and Muscle
 Heart Antibodies  XK antibody  >14 publications with XK and Heart
 Liver Antibodies  XK antibody  >8 publications with XK and Liver
 Nerve Antibodies  XK antibody  >7 publications with XK and Nerve
 Testis Antibodies  XK antibody  >5 publications with XK and Testis
 Eye Antibodies  XK antibody  >4 publications with XK and Eye
 Intestine Antibodies  XK antibody  >2 publications with XK and Intestine
 Embryonic Tissue Antibodies  XK antibody  >2 publications with XK and Embryonic Tissue
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