AAB41835.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,731 Da
NCBI Official Full Name
paraoxonase
NCBI Official Synonym Full Names
paraoxonase 1
NCBI Protein Information
serum paraoxonase/arylesterase 1; A-esterase 1; K-45; PON 1; aromatic esterase 1; arylesterase B-type; esterase A; paraoxonase B-type; serum aryldiakylphosphatase; serum aryldialkylphosphatase 1
UniProt Protein Name
Serum paraoxonase/arylesterase 1
UniProt Synonym Protein Names
Aromatic esterase 1; A-esterase 1; K-45; Serum aryldialkylphosphatase 1
UniProt Synonym Gene Names
UniProt Entry Name
PON1_HUMAN
NCBI Summary for PON1
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008]
UniProt Comments for PON1
PON1: Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. Genetic variation in PON1 is associated with susceptibility to microvascular complications of diabetes type 5 (MVCD5). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Homozygosity for the Leu-54 allele is strongly associated with the development of retinal disease in diabetic patients. Belongs to the paraoxonase family.
Protein type: EC 3.1.1.81; Lipid-binding; Secreted; Hydrolase; Secreted, signal peptide; Phosphatase (non-protein); EC 3.1.1.2; EC 3.1.8.1; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q21.3
Cellular Component: extracellular space; intracellular membrane-bound organelle; extracellular region
Molecular Function: protein homodimerization activity; arylesterase activity; phospholipid binding; calcium ion binding; aryldialkylphosphatase activity
Biological Process: response to nutrient levels; response to external stimulus; dephosphorylation; organophosphate catabolic process; response to toxin; positive regulation of transporter activity; carboxylic acid catabolic process; positive regulation of binding; aromatic compound catabolic process; phosphatidylcholine metabolic process
Disease: Microvascular Complications Of Diabetes, Susceptibility To, 5
Research Articles on PON1
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Products associated with PON1 elisa kit
Pathways associated with PON1 elisa kit
Diseases associated with PON1 elisa kit
Organs/Tissues associated with PON1 elisa kit
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