View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List anti-p53 antibody :: Rabbit anti-Human p53 Polyclonal Antibody Catalog # MBS302070 Unit / Price DISCONTINUEDYou will be redirected to our replacement product Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name p53, Polyclonal Antibody Full Product Name Rabbit Anti-Human p53 Polyclonal Antibody Product Gene Name anti-p53 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM 133239 Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human Form/Format 0.5 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide. Immunogen Recombinant human full length wild type p53 protein. Control Tissue Colon Carcinoma Cellular Localization Nucleus Entrez Gene Code 7157 Pathway Cell Cycle Preparation and Storage Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support. Other Notes Small volumes of anti-p53 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-p53 antibody p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein. p53 senses DNA damage and possibly facilitates repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma. Applications Tested/Suitable for anti-p53 antibody Immunohistochemistry (IHC) Paraffin Application Notes for anti-p53 antibody Immunohistochemistry ProcedureSpecimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format for this product, dilute the antibody 1:100. The dilutions may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at RT. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system.Immunohistochemistry Dilution: 1:50IHC Positive Control: Colon Adenoarcinoma Immunohistochemistry (IHC) of anti-p53 antibody Human colon adenocarcinoma stained with anti-p53 antibody TOP NCBI/Uniprot data below describe general gene information for p53. It may not necessarily be applicable to this product. NCBI GI # 120407068 NCBI GeneID 7157 NCBI Accession # NP_000537.3 [Other Products] NCBI GenBank Nucleotide # NM_000546.5 [Other Products] UniProt Secondary Accession # Q15086; Q15087; Q15088; Q16535; Q16807; Q16808; Q16809; Q16810; Q16811; Q16848; Q2XN98[Other Products] UniProt Related Accession # P04637[Other Products] Molecular Weight 53 kDa TOP NCBI Official Full Name cellular tumor antigen p53 isoform a NCBI Official Synonym Full Names tumor protein p53 NCBI Official Symbol TP53 [Similar Products] NCBI Official Synonym Symbols P53; BCC7; LFS1; TRP53 [Similar Products] NCBI Protein Information cellular tumor antigen p53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53 UniProt Protein Name Cellular tumor antigen p53 UniProt Synonym Protein Names Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 Protein Family p53 and DNA damage-regulated protein UniProt Gene Name TP53 [Similar Products] UniProt Synonym Gene Names P53 [Similar Products] UniProt Entry Name P53_HUMAN TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Pathways associated with anti-p53 antibody Products by Pathway Pathway Diagram AMPK Signaling Pathway antibodies AMPK Signaling Pathway Diagram Activation Of BH3-only Proteins Pathway antibodies Activation Of BH3-only Proteins Pathway Diagram Activation Of NOXA And Translocation To Mitochondria Pathway antibodies Activation Of NOXA And Translocation To Mitochondria Pathway Diagram Activation Of PUMA And Translocation To Mitochondria Pathway antibodies Activation Of PUMA And Translocation To Mitochondria Pathway Diagram Alzheimers Disease Pathway antibodies Alzheimers Disease Pathway Diagram Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Diseases associated with anti-p53 antibody Disease Name Pubmed Publications Carcinoma Antibodies >2847 publications with p53 and Carcinoma Breast Neoplasms Antibodies >1079 publications with p53 and Breast Neoplasms Colorectal Neoplasms Antibodies >721 publications with p53 and Colorectal Neoplasms Carcinoma, Squamous Cell Antibodies >685 publications with p53 and Carcinoma, Squamous Cell Glioma Antibodies >583 publications with p53 and Glioma Carcinoma, Small Cell Antibodies >413 publications with p53 and Carcinoma, Small Cell Neoplasm Metastasis Antibodies >406 publications with p53 and Neoplasm Metastasis Cell Transformation, Neoplastic Antibodies >404 publications with p53 and Cell Transformation, Neoplastic Sarcoma Antibodies >346 publications with p53 and Sarcoma Liver Neoplasms Antibodies >345 publications with p53 and Liver Neoplasms Organs/Tissues associated with anti-p53 antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >919 publications with p53 and Blood Lung Antibodies >782 publications with p53 and Lung Brain Antibodies >626 publications with p53 and Brain Liver Antibodies >435 publications with p53 and Liver Bone Antibodies >329 publications with p53 and Bone Skin Antibodies >316 publications with p53 and Skin Lymph Node Antibodies >312 publications with p53 and Lymph Node Lymph Antibodies >304 publications with p53 and Lymph Bladder Antibodies >298 publications with p53 and Bladder Prostate Antibodies >228 publications with p53 and Prostate TOP © 2006-24 MyBioSource.com. 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