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GH recombinant protein :: growth hormone (zfGH) [Recombinant Protein]
Catalog #    MBS400097
Unit / Price
0.01 mg  /  $160.00 + 1 FREE 8GB USB Flash Drive
0.05 mg  /  $205.00 + 1 FREE 8GB USB Flash Drive
0.1 mg  /  $270.00 + 1 FREE 8GB USB Flash Drive
0.5 mg  /  $655.00 + 1 FREE 8GB USB Flash Drive
1 mg  /  $1,105.00 + 1 FREE 8GB USB Flash Drive
5 mg  /  $4,450.00 + 5 FREE 8GB USB Flash Drive
10 mg  /  $7,315.00 + 9 FREE 8GB USB Flash Drive
    
 Go to:     Product Names    Product Info    Accession #s    Product Desc    Diseases/Tissues/Pathways    Applications    References 
 Product Name    growth hormone (zfGH), Recombinant Protein
 Also Known As    Zebrafish growth hormone (zfGH)
 Product Synonym Names    Zebrafish growth hormone
 Product Gene Name    GH recombinant protein [Similar Products]
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 Immunogen Sequence Length    217
 Immunogen Sequence    The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Gln-Ar g-Leu-Phe- Asn.
 Chromosome Location    Chromosome: 17; NC_000017.10 (61994560..61996206, complement). Location: 17q24.2
 OMIM    139250
 3D Structure    ModBase 3D Structure for P01241
 Host    E Coli
 Purity/Purification    Greater than 99.0% as determined by:
(a) Gel filtration analysis.
(b) Analysis by reducing and non-reducing SDS-PAGE gel.
(c) Analysis by RP-HPLC.
 Form/Format    The protein was lyophilized from a concentrated (1mg/ml) solution with 0.5% NaHCO3 adjusted to pH 8.
Physical Appearance: White lyophilized (freeze-dried) powder.
 Dimers and Aggregates    The purified zfGH (21K) consists of > 99% monomers as determined by gel-filtration chromatography.
 Biological Activity    zfGH is biologically active in PDF-P1 3B9 cells stably transfected with rabbit GH receptors.
 Endotoxin    Less than 0.05 ng/ug (IEU/ug) of zfGH (22 K).
 Protein Content    Protein quantitation was carried out by UV spectroscopy at 280 nm using the absorbency value of 0.42 as the extinction coefficient for a 0.1% (1mg/ml) solution at pH 8.0 This value is calculated by the DNAman program.
 Solubility    It is recommended to reconstitute the lyophilized zfGH in sterile water or 0.4% NaHCO3 adjusted to pH 8-9, not less than 100ug/ml and not more than 3 mg/ml, which can then be further diluted to other aqueous solutions, preferably in presence of carrier protein.
 Preparation and Storage    Lyophilized zfGH although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution at > 0.1 mg/ml and filter sterilization zfGH can be stored at 4C for several weeks. At lower concentration addition of a carrier protein (0.1% HSA or BSA) is recomended. Please prevent freeze-thaw cycles.
 Other Notes for GH recombinant protein    Small volumes of GH recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
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 Product Description specifically for GH recombinant protein    Recombinant zebrafish growth hormone (zbGH) produced in E.Coli (22 K) is a single, non-glycosylated, polypeptide chain containing 185 amino acids with an additional Ala at its N-terminus and having a molecular mass of 21187 Dalton. zfGH is purified by proprietary chromatographic techniques.
 Product Categories/Family for GH recombinant protein    Growth hormone and prolactin family; Growth hormones, prolactins, placental lactogens
NCBI/Uniprot data below describe general gene information for GH. It may not necessarily be applicable to this product.
 NCBI GI #    183157 [Other Products]
 NCBI GeneID    2688 [Other Products]
 NCBI Accession #    AAA98618.1 [Other Products]
 UniProt Primary Accession #    P01241 [Other Products]
 UniProt Secondary Accession #    Q14405; Q16631; Q5EB53; Q9HBZ1; Q9UMJ7; Q9UNL5; A6NEF6 [Other Products]
 UniProt Related Accession #    P01241 [Other Products]
 Molecular Weight    24,847 Da
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 NCBI Official Full Name    growth hormone
 NCBI Official Synonym Full Names    growth hormone 1
 NCBI Official Symbol    GH1 [Similar Products]
 NCBI Official Synonym Symbols    GH; GHN; GH-N; hGH-N; IGHD1B [Similar Products]
 NCBI Protein Information    somatotropin; pituitary growth hormone
 UniProt Protein Name    Somatotropin
 UniProt Synonym Protein Names    Growth hormone; GH; GH-N; Growth hormone 1; Pituitary growth hormone
 UniProt Gene Name    GH1 [Similar Products]
 UniProt Synonym Gene Names    GH; GH-N [Similar Products]
 UniProt Entry Name    SOMA_HUMAN
 NCBI Summary for GH    The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]
 UniProt Comments for GH    Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Subunit structure: Monomer, dimer, trimer, tetramer and pentamer, disulfide-linked or non-covalently associated, in homopolymeric and heteropolymeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex.

Subcellular location: Secreted.

Involvement in disease: Growth hormone deficiency, isolated, 1A (IGHD1A) [MIM:262400]: An autosomal recessive, severe deficiency of growth hormone leading to dwarfism. Patients often develop antibodies to administered growth hormone.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.22Growth hormone deficiency, isolated, 1B (IGHD1B) [MIM:612781]: An autosomal recessive deficiency of growth hormone leading to short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.33 Ref.38Kowarski syndrome (KWKS) [MIM:262650]: A syndrome clinically characterized by short stature associated with bioinactive growth hormone, normal or slightly increased growth hormone secretion, pathologically low insulin-like growth factor 1 levels, and normal catch-up growth on growth hormone replacement therapy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.31 Ref.34 Ref.41Growth hormone deficiency, isolated, 2 (IGHD2) [MIM:173100]: An autosomal dominant deficiency of growth hormone leading to short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.33 Ref.37

Pharmaceutical use: Available under the names Nutropin or Protropin (Genentech), Norditropin (Novo Nordisk), Genotropin (Pharmacia Upjohn), Humatrope (Eli Lilly) and Saizen or Serostim (Serono). Used for the treatment of growth hormone deficiency and for Turner's syndrome.

Miscellaneous: Circulating GH shows a great heterogeneity due to alternative splicing, differential post-translational modifications of monomeric forms, oligomerization, optional binding to 2 different GH-binding proteins, and potentially proteolytic processing.

Sequence similarities: Belongs to the somatotropin/prolactin family.
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 NCBI References for GH    1. Distinct chromatin configurations regulate the initiation and the maintenance of hGH gene expression.
2. Short stature in two siblings heterozygous for a novel bioinactive GH mutant (GH-P59S) suggesting that the mutant also affects secretion of the wild-type GH.
3. Isolated growth hormone deficiency type 2: from gene to therapy.
4. Bioinformatics tools and databases for the study of human growth hormone.
5. Association between serum growth hormone levels and nonalcoholic fatty liver disease: a cross-sectional study.
 UniProt References for GH    • Molecular cloning and nucleotide sequence of the human growth hormone structural gene. Roskam W., Rougeon F.Nucleic Acids Res. 7:305-320(1979) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
• Human growth hormone: complementary DNA cloning and expression in bacteria. Martial J.A., Hallewell R.A., Baxter J.D., Goodman H.M.Science 205:602-607(1979) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
• Human growth hormone DNA sequence and mRNA structure: possible alternative splicing. Denoto F.M., Moore D.D., Goodman H.M.Nucleic Acids Res. 9:3719-3730(1981) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), POSSIBLE ALTERNATIVE SPLICING.
• The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone. Seeburg P.H.DNA 1:239-249(1982) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• The human growth hormone locus: nucleotide sequence, biology, and evolution. Chen E.Y., Liao Y.C., Smith D.H., Barrera-Saldana H.A., Gelinas R.E., Seeburg P.H.Genomics 4:479-497(1989) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
 Research Articles on GH    1. in SHOX deficiency subjects an altered GH secretion is not uncommon, and rhGH therapy may be effective in increasing height in most of these patients independent of GH secretion, without causing adverse events of concern.
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 Searchable Name for GH    anti-GH; Buy GH recombinant protein :: growth hormone (zfGH), Recombinant Protein (MBS400097) datasheet at MyBioSource; anti-GH; GH; GHN; GH-N; hGH-N; IGHD1B; GH; GH-N; anti-growth hormone (zfGH); Zebrafish growth hormone (zfGH); Zebrafish growth hormone; growth hormone; growth hormone 1; Somatotropin; Growth hormone; GH; GH-N; Growth hormone 1; Pituitary growth hormone E Coli . (NCBI/UniProt 183157 AAA98618.1 P01241 P01241 Q14405; Q16631; Q5EB53; Q9HBZ1; Q9UMJ7; Q9UNL5; A6NEF6 24,847 Da); Growth hormone and prolactin family; Growth hormones, prolactins, placental lactogens; Chromosome: 17; NC_000017.10 (61994560..61996206, complement). Location: 17q24.2; 2688; SOMA_HUMAN; GH recombinant protein; anti-GH
 Precautions    This product is for research use only. Not for use in diagnostic or therapeutic procedures.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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Products associated with GH recombinant proteinPathways associated with GH recombinant protein
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 Product Name  Products by Pathway  Pathway Diagram
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 GH recombinant protein  Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
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Diseases associated with GH recombinant proteinOrgans/Tissues associated with GH recombinant protein
 Disease Name  Ref Prod  Pubmed Publications
 Neoplasms Antibodies  anti-GH  >66 publications with GH and Neoplasms
 Nervous System Diseases Antibodies  anti-GH  >61 publications with GH and Nervous System Diseases
 Pituitary Neoplasms Antibodies  anti-GH  >42 publications with GH and Pituitary Neoplasms
 Growth Disorders Antibodies  anti-GH  >25 publications with GH and Growth Disorders
 Breast Neoplasms Antibodies  anti-GH  >9 publications with GH and Breast Neoplasms
 Insulin Resistance Antibodies  anti-GH  >6 publications with GH and Insulin Resistance
 Cardiovascular Diseases Antibodies  anti-GH  >5 publications with GH and Cardiovascular Diseases
 Obesity Antibodies  anti-GH  >5 publications with GH and Obesity
 Liver Diseases Antibodies  anti-GH  >5 publications with GH and Liver Diseases
 Weight Gain Antibodies  anti-GH  >5 publications with GH and Weight Gain
 Organ/Tissue Name  Ref Prod  Pubmed Publications
 Pituitary Gland Antibodies  GH antibody  >46 publications with GH and Pituitary Gland
 Brain Antibodies  GH antibody  >43 publications with GH and Brain
 Placenta Antibodies  GH antibody  >6 publications with GH and Placenta
 Prostate Antibodies  GH antibody  >2 publications with GH and Prostate
 Ear Antibodies  GH antibody  >1 publications with GH and Ear
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