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GDF11 recombinant protein :: GDF11 [Recombinant Protein]
Catalog #    MBS538017
Unit / Price
0.02 mg  /  $320.00 + 1 FREE 8GB USB Flash Drive
    
 Go to:     Product Names    Product Info    Accession #s    Product Desc    Diseases/Tissues/Pathways    Applications    References 
 Product Name    GDF11, Recombinant Protein
 Also Known As    GDF11 protein
 Product Synonym Names    BMP-11 protein; GDF 11 protein; GDF-11 protein; GDF-11 protein; GDF-11; Growth/Differentiation Factor-11 protein; GDF11; GDF 11
 Product Gene Name    GDF11 recombinant protein [Similar Products]
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 Chromosome Location    Chromosome: 12; NC_000012.11 (56137064..56146665). Location: 12q13.2
 OMIM    603936
 3D Structure    ModBase 3D Structure for O95390
 Host    E.coli
 Species Reactivity    Human
 Purity/Purification    >98% pure by SDS PAGE and HPLC
 Form/Format    Supplied lyophilized with no additives. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Keep pH below 5.0.
 Concentration    20 ug per vial: lyophiliezed
 Residues    Region of GDF11 protein corresponding to amino acids NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS.
 Endotoxin Level    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Bioactivity    The ED50 was determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10 ug/ml.
 Additional Remarks    The Biological activity is determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effet is 0.08-1.0ug/ml.
 Preparation and Storage    Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes for GDF11 recombinant protein    Small volumes of GDF11 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
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 Product Description specifically for GDF11 recombinant protein    Purified recombinant Human GDF11 protein
GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same.
 Product Categories/Family for GDF11 recombinant protein    Cytokines & Growth Factors; Proteins; Native & Recombinant Proteins; Recombinant
NCBI/Uniprot data below describe general gene information for GDF11. It may not necessarily be applicable to this product.
 NCBI GI #    5031613 [Other Products]
 NCBI GeneID    10220 [Other Products]
 NCBI Accession #    NP_005802.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005811.3 [Other Products]
 UniProt Primary Accession #    O95390 [Other Products]
 UniProt Secondary Accession #    Q9UID1; Q9UID2 [Other Products]
 UniProt Related Accession #    O95390 [Other Products]
 Molecular Weight    25 kDa
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 NCBI Official Full Name    growth/differentiation factor 11
 NCBI Official Synonym Full Names    growth differentiation factor 11
 NCBI Official Symbol    GDF11 [Similar Products]
 NCBI Official Synonym Symbols    BMP11; BMP-11 [Similar Products]
 NCBI Protein Information    growth/differentiation factor 11; GDF-11; bone morphogenetic protein 11
 UniProt Protein Name    Growth/differentiation factor 11
 UniProt Synonym Protein Names    Bone morphogenetic protein 11
 UniProt Gene Name    GDF11 [Similar Products]
 UniProt Synonym Gene Names    BMP11; GDF-11; BMP-11 [Similar Products]
 UniProt Entry Name    GDF11_HUMAN
 NCBI Summary for GDF11    The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]
 UniProt Comments for GDF11    Function: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.

Subunit structure: Homodimer; disulfide-linked

By similarity.

Subcellular location: Secreted

Probable.

Sequence similarities: Belongs to the TGF-beta family.
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 NCBI References for GDF11    1. A large-scale candidate gene association study of age at menarche and age at natural menopause.
2. BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures.
3. Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11.
4. Differential antagonism of activin, myostatin and growth and differentiation factor 11 by wild-type and mutant follistatin.
5. VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5.
 UniProt References for GDF11    • A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos. Gamer L.W., Wolfman N.M., Celeste A.J., Hattersley G., Hewick R., Rosen V.Dev. Biol. 208:222-232(1999) [PubMed: 10075854] [Abstract]
 Research Articles on GDF11    1. Observational study of gene-disease association. (HuGE Navigator)
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 Searchable Name for GDF11    anti-GDF11; Buy GDF11 recombinant protein :: GDF11, Recombinant Protein (MBS538017) datasheet at MyBioSource; anti-GDF11; BMP11; BMP-11; BMP11; GDF-11; BMP-11; anti-GDF11; GDF11 protein; BMP-11 protein; GDF 11 protein; GDF-11 protein; GDF-11 protein; GDF-11; Growth/Differentiation Factor-11 protein; GDF11; GDF 11; growth/differentiation factor 11; growth differentiation factor 11; Growth/differentiation factor 11; Bone morphogenetic protein 11 E.coli anti-Human. (NCBI/UniProt 5031613 NP_005802.1 O95390 NM_005811.3 O95390 Q9UID1; Q9UID2 25 kDa); Cytokines & Growth Factors; Proteins; Native & Recombinant Proteins; Recombinant ; Chromosome: 12; NC_000012.11 (56137064..56146665). Location: 12q13.2; 10220; GDF11_HUMAN; GDF11 recombinant protein; anti-GDF11
 Precautions    This product is for research use only. Not for use in diagnostic or therapeutic procedures.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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Products associated with GDF11 recombinant proteinDiseases associated with GDF11 recombinant protein
 Product Name  Ref Prod  PubMed Publications
 GDF11 recombinant protein  ACVR2B recombinant protein  >3 publications with GDF11 and ACVR2B
 Disease Name  Ref Prod  Pubmed Publications
 Caudal regression syndrome Antibodies  anti-GDF11  >2 publications with GDF11 and Caudal regression syndrome
 Disease Models, Animal Antibodies  anti-GDF11  >2 publications with GDF11 and Disease Models, Animal
 Eye Abnormalities Antibodies  anti-GDF11  >2 publications with GDF11 and Eye Abnormalities
 Fatty Liver Antibodies  anti-GDF11  >1 publications with GDF11 and Fatty Liver
 Nephrosis Antibodies  anti-GDF11  >1 publications with GDF11 and Nephrosis
 Necrosis Antibodies  anti-GDF11  >1 publications with GDF11 and Necrosis
 Neoplasm Metastasis Antibodies  anti-GDF11  >1 publications with GDF11 and Neoplasm Metastasis
Organs/Tissues associated with GDF11 recombinant protein
 Organ/Tissue Name  Ref Prod  Pubmed Publications
 Bone Antibodies  GDF11 antibody  >58 publications with GDF11 and Bone
 Muscle Antibodies  GDF11 antibody  >17 publications with GDF11 and Muscle
 Embryonic Tissue Antibodies  GDF11 antibody  >13 publications with GDF11 and Embryonic Tissue
 Nerve Antibodies  GDF11 antibody  >11 publications with GDF11 and Nerve
 Kidney Antibodies  GDF11 antibody  >8 publications with GDF11 and Kidney
 Eye Antibodies  GDF11 antibody  >6 publications with GDF11 and Eye
 Pancreas Antibodies  GDF11 antibody  >5 publications with GDF11 and Pancreas
 Mouth Antibodies  GDF11 antibody  >4 publications with GDF11 and Mouth
 Heart Antibodies  GDF11 antibody  >4 publications with GDF11 and Heart
 Liver Antibodies  GDF11 antibody  >3 publications with GDF11 and Liver
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