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ND2 antibody :: mitochondrially encoded NADH dehydrogenase 2 [Polyclonal Antibody]
Catalog #    MBS713637
Unit / Price
0.05 ml  /  $385.00 + 1 FREE 8GB USB Flash Drive
0.15 ml  /  $745.00 + 1 FREE 8GB USB Flash Drive
    
 Go to:     Product Names    Product Info    Accession #s    Product Desc    Diseases/Tissues/Pathways    Applications    References 
 Product Name    mitochondrially encoded NADH dehydrogenase 2, Antibody
 Also Known As    Rabbit anti-human mitochondrially encoded NADH dehydrogenase 2 polyclonal Antibody
 Product Synonym Names    NADH dehydrogenase; subunit 2 (complex I); ND2; MTND2
 Product Gene Name    ND2 antibody [Similar Products]
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 Chromosome Location    Chromosome: MT; NC_012920.1 (4470..5511). Location: country: United Kingdom: Great Britain, tissue type: placenta, isolation source: caucasian
 OMIM    502500
 3D Structure    ModBase 3D Structure for P03891
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
 Purity/Purification    Antigen Affinity purified
 Immunogen    Human ND2
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Other Notes for ND2 antibody    Small volumes of ND2 antibody may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
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 Applications Tested/Suitable for ND2 antibody    ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
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NCBI/Uniprot data below describe general gene information for ND2. It may not necessarily be applicable to this product.
 NCBI GI #    251831108 [Other Products]
 NCBI GeneID    4536 [Other Products]
 NCBI Accession #    YP_003024027.1 [Other Products]
 NCBI GenBank Nucleotide #    NC_012920.1 [Other Products]
 UniProt Primary Accession #    P03891 [Other Products]
 UniProt Secondary Accession #    Q34769; Q9TGI0; Q9TGI1; Q9TGI2; Q9TGI3; Q9TGI4 [Other Products]
 Molecular Weight    38,961 Da
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 NCBI Official Full Name    NADH dehydrogenase subunit 2
 NCBI Official Symbol    ND2 [Similar Products]
 NCBI Official Synonym Symbols    MTND2 [Similar Products]
 NCBI Protein Information    MTND2; NADH dehydrogenase subunit 2
 UniProt Protein Name    NADH-ubiquinone oxidoreductase chain 2
 UniProt Synonym Protein Names    NADH dehydrogenase subunit 2
 UniProt Gene Name    MT-ND2 [Similar Products]
 UniProt Synonym Gene Names    MTND2; NADH2; ND2 [Similar Products]
 UniProt Entry Name    NU2M_HUMAN
 UniProt Comments for ND2    Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

By similarity.

Catalytic activity: NADH + ubiquinone = NAD+ + ubiquinol.

Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein.

Involvement in disease: Defects in MT-ND2 are a cause of Leber hereditary optic neuropathy (LHON) [

MIM:535000]. LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Ref.12 Ref.14Defects in MT-ND2 may be associated with susceptibility to Alzheimer disease mitochondrial (AD-MT) [

MIM:502500]. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. Ref.15

Sequence similarities: Belongs to the complex I subunit 2 family.

Sequence caution: The sequence AAA65502.1 differs from that shown. Reason: Erroneous initiation.
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 NCBI References for ND2    1. Joint effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on risk of hyper-LDL cholesterolemia in middle-aged Japanese men.
2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
3. MtSNPscore: a combined evidence approach for assessing cumulative impact of mitochondrial variations in disease.
4. NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of coffee consumption on the risk of hypertension in middle-aged Japanese men.
5. Mitochondrial polymorphisms are associated both with increased and decreased longevity.
 UniProt References for ND2    • Sequence and organization of the human mitochondrial genome. Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R., Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H., Smith A.J.H., Staden R., Young I.G.Nature 290:457-465(1981) [PubMed: 7219534] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
• Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing. Sanger F., Coulson A.R., Barrell B.G., Smith A.J.H., Roe B.A.J. Mol. Biol. 143:161-178(1980) [PubMed: 6260957] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• Departure from neutrality at the mitochondrial NADH dehydrogenase subunit 2 gene in humans, but not in chimpanzees. Wise C.A., Sraml M., Easteal S.Genetics 148:409-421(1998) [PubMed: 9475751] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-69; SER-88; ASP-150; MET-237; THR-265; VAL-265; THR-278 AND ALA-333.
• Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs. Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995) [PubMed: 7530363] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-43; LEU-325 AND THR-331. Tissue: Placenta.
• Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J. Moilanen J.S., Finnila S., Majamaa K.Mol. Biol. Evol. 20:2132-2142(2003) [PubMed: 12949126] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
 Research Articles on ND2    1. For Mt5178C genotypic men, alcohol consumption may reduce the risk of hyper-LDL cholesterolemia
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 Searchable Name for ND2    anti-ND2; Buy ND2 antibody :: mitochondrially encoded NADH dehydrogenase 2, Polyclonal Antibody (MBS713637) datasheet at MyBioSource; anti-ND2; MTND2; MTND2; NADH2; ND2; anti-mitochondrially encoded NADH dehydrogenase 2; Rabbit anti-human mitochondrially encoded NADH dehydrogenase 2 polyclonal Antibody ; NADH dehydrogenase; subunit 2 (complex I); ND2; MTND2; NADH dehydrogenase subunit 2; NADH-ubiquinone oxidoreductase chain 2; NADH dehydrogenase subunit 2 Rabbit anti-Human. (Tested application: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)) (NCBI/UniProt 251831108 YP_003024027.1 NC_012920.1 P03891 Q34769; Q9TGI0; Q9TGI1; Q9TGI2; Q9TGI3; Q9TGI4 38,961 Da); IgG; Chromosome: MT; NC_012920.1 (4470..5511). Location: country: United Kingdom: Great Britain, tissue type: placenta, isolation source: caucasian; 4536; NU2M_HUMAN; ND2 antibody; anti-ND2
 Precautions    This product is for research use only. Not for use in diagnostic or therapeutic procedures.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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Products associated with ND2 antibodyPathways associated with ND2 antibody
 Product Name  Ref Prod  PubMed Publications
 ND2 antibody  SRC antibody  >2 publications with ND2 and SRC
 Product Name  Products by Pathway  Pathway Diagram
 ND2 antibody  Electron Transport Chain Pathway antibodies  Electron Transport Chain Pathway Diagram
 ND2 antibody  Metabolism Pathway antibodies  Metabolism Pathway Diagram
 ND2 antibody  NADH:ubiquinone Oxidoreductase, Mitochondria Pathway antibodies  NADH:ubiquinone Oxidoreductase, Mitochondria Pathway Diagram
 ND2 antibody  Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 ND2 antibody  Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 ND2 antibody  Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 ND2 antibody  Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 ND2 antibody  Respiratory Electron Transport Pathway antibodies  Respiratory Electron Transport Pathway Diagram
 ND2 antibody  Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway antibodies  Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway Diagram
 ND2 antibody  The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway antibodies  The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway Diagram
Diseases associated with ND2 antibody
 Disease Name  Ref Prod  Pubmed Publications
 Neoplasms Antibodies  anti-ND2  >54 publications with ND2 and Neoplasms
 Nervous System Diseases Antibodies  anti-ND2  >32 publications with ND2 and Nervous System Diseases
 Brain Diseases Antibodies  anti-ND2  >23 publications with ND2 and Brain Diseases
 Mitochondrial Diseases Antibodies  anti-ND2  >19 publications with ND2 and Mitochondrial Diseases
 Immune System Diseases Antibodies  anti-ND2  >10 publications with ND2 and Immune System Diseases
 Drug Toxicity Antibodies  anti-ND2  >6 publications with ND2 and Drug Toxicity
 Hypertension Antibodies  anti-ND2  >6 publications with ND2 and Hypertension
 Liver Neoplasms Antibodies  anti-ND2  >5 publications with ND2 and Liver Neoplasms
 Lung Neoplasms Antibodies  anti-ND2  >4 publications with ND2 and Lung Neoplasms
 Heart Diseases Antibodies  anti-ND2  >4 publications with ND2 and Heart Diseases
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