NP_001962.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,798 Da
NCBI Official Full Name
chymotrypsin-like elastase family member 1
NCBI Official Synonym Full Names
chymotrypsin-like elastase family, member 1
NCBI Official Synonym Symbols
NCBI Protein Information
chymotrypsin-like elastase family member 1; elastase-1; pancreatic elastase 1; elastase 1, pancreatic
UniProt Protein Name
Chymotrypsin-like elastase family member 1
UniProt Synonym Protein Names
Elastase-1; Pancreatic elastase 1
UniProt Synonym Gene Names
UniProt Entry Name
CELA1_HUMAN
NCBI Summary for ELA1
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B. [provided by RefSeq, May 2009]
UniProt Comments for ELA1
CELA1: Acts upon elastin. Belongs to the peptidase S1 family. Elastase subfamily.
Protein type: Protease; Secreted, signal peptide; EC 3.4.21.36; Secreted
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: extracellular region
Molecular Function: metal ion binding; serine-type endopeptidase activity
Biological Process: Wnt receptor signaling pathway; multicellular organism growth; regulation of cell differentiation; exocrine pancreas development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; inflammatory response; proteolysis; post-embryonic development; regulation of cell proliferation
Research Articles on ELA1
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