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cTn1 elisa kit :: Cardiac Troponin 1 [ELISA Kit]
Catalog #    MBS729403
Unit / Price
48 Strip Wells  /  $545.00 + 1 FREE 8GB USB Flash Drive
96 Strip Wells  /  $800.00 + 1 FREE 8GB USB Flash Drive
    
 Go to:     Product Names    Product Info    Accession #s    Product Desc    Diseases/Tissues/Pathways    Applications    References 
 Product Name    Cardiac Troponin 1, ELISA Kit
 Also Known As    Human Cardiac Troponin 1 ELISA Kit
 Product Gene Name    cTn1 elisa kit [Similar Products]
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 cTn1 elisa kit Manual   
 Chromosome Location    Chromosome: 19; NC_000019.9 (55663135..55669100, complement). Location: 19q13.4
 3D Structure    ModBase 3D Structure for Q6FGX2
 Species Reactivity    Human
 Preparation and Storage    Store all reagents at 2-8 degree C
 Other Notes for cTn1 elisa kit    Small volumes of cTn1 elisa kit may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
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 Product Description specifically for cTn1 elisa kit    Intended Uses: This cTnI ELISA kit is intended Laboratory for research use only and is not for use in diagnostic or therapeutic procedures.The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration of cTnI in the sample, this cTnI ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versus cTnI concentration. The concentration of cTnI in the samples is then determined by comparing the O.D. of the samples to the standard curve.

Principle of the Assay: This cTnI enzyme linked immunosorbent assay applies a technique called a quantitative sandwich immunoassay. The microtiter plate provided in this kit has been pre-coated with a monoclonal antibody specific for cTnI. Standards or samples are then added to the microtiter plate wells and cTnI if present, will bind to the antibody pre-coated wells. In order to quantitatively determine the amount of cTnI present in the sample, a standardized preparation of horseradish peroxidase (HRP)-conjugated polyclonal antibody, specific for cTnI are added to each well to "sandwich" the cTnI immobilized on the plate. The microtiter plate undergoes incubation, and then the wells are thoroughly washed to remove all unbound components. Next, A and B substrate solution is added to each well. The enzyme (HRP) and substrate are allowed to react over a short incubation period.Only those wells that contain cTnI and enzyme-conjugated antibody will exhibit a change in colour. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the colour change is measured spectrophotometrically at a wavelength of 450 nm.
 Product Categories/Family for cTn1 elisa kit    Cardiovascular
NCBI/Uniprot data below describe general gene information for cTn1. It may not necessarily be applicable to this product.
 NCBI GI #    49456923 [Other Products]
 NCBI GeneID    7137 [Other Products]
 NCBI Accession #    CAG46782 [Other Products]
 UniProt Primary Accession #    Q6FGX2 [Other Products]
 UniProt Related Accession #    P19429 [Other Products]
 Molecular Weight    24,008 Da
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 NCBI Official Full Name    TNNI3
 NCBI Official Synonym Full Names    troponin I type 3 (cardiac)
 NCBI Official Symbol    TNNI3 [Similar Products]
 NCBI Official Synonym Symbols    CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF [Similar Products]
 NCBI Protein Information    troponin I, cardiac muscle
 UniProt Protein Name    TNNI3 protein
 UniProt Gene Name    TNNI3 [Similar Products]
 UniProt Entry Name    Q6FGX2_HUMAN
 NCBI Summary for cTn1    Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
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 NCBI References for cTn1    1. Prognostic value of cardiac troponin levels in infective endocarditis.
2. Integration of troponin I phosphorylation with cardiac regulatory networks.
3. Possible regulatory roles of promoter g-quadruplexes in cardiac function-related genes - human TnIc as a model.
4. Cardiac troponins I and T: molecular markers for early diagnosis, prognosis, and accurate triaging of patients with acute myocardial infarction.
5. Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes.
 UniProt References for cTn1    • Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Maruyama K., Sugano S.Gene 138:171-174(1994) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE. Tissue: Heart EMBL BAD97171.1.
• Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Suzuki Y., Yoshitomo K., Maruyama K., Suyama A., Sugano S.Gene 200:149-156(1997) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE. Tissue: Heart EMBL BAD97171.1.
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
• Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE.
• Cloning of human full-length CDSs in BD Creator(TM) System Donor vector. Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE.
 Research Articles on cTn1    1. Reviewed reports suggest Tn elevation commonly occurs in the setting of infectious encocarditis.
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 Searchable Name for cTn1    anti-cTn1; Buy cTn1 elisa kit :: Cardiac Troponin 1, ELISA Kit (MBS729403) datasheet at MyBioSource; anti-cTn1; CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; anti-Cardiac Troponin 1; Human Cardiac Troponin 1 ELISA Kit; TNNI3; troponin I type 3 (cardiac); TNNI3 protein anti-Human. (NCBI/UniProt 49456923 CAG46782 P19429 Q6FGX2 24,008 Da); Cardiovascular ; Chromosome: 19; NC_000019.9 (55663135..55669100, complement). Location: 19q13.4; 7137; Q6FGX2_HUMAN; cTn1 elisa kit; anti-cTn1
 Precautions    This product is for research use only. Not for use in diagnostic or therapeutic procedures.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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Pathways associated with cTn1 elisa kitDiseases associated with cTn1 elisa kit
 Product Name  Products by Pathway  Pathway Diagram
 cTn1 elisa kit  Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 cTn1 elisa kit  Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 cTn1 elisa kit  Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 cTn1 elisa kit  Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 cTn1 elisa kit  Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 cTn1 elisa kit  Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 cTn1 elisa kit  Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 cTn1 elisa kit  Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 cTn1 elisa kit  Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
 cTn1 elisa kit  Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
 Disease Name  Ref Prod  Pubmed Publications
 Cardiovascular Diseases Antibodies  anti-cTn1  >67 publications with cTn1 and Cardiovascular Diseases
 Heart Diseases Antibodies  anti-cTn1  >66 publications with cTn1 and Heart Diseases
 Cardiomyopathies Antibodies  anti-cTn1  >57 publications with cTn1 and Cardiomyopathies
 Cardiomyopathy, Hypertrophic, Familial Antibodies  anti-cTn1  >25 publications with cTn1 and Cardiomyopathy, Hypertrophic, Familial
 Hypertrophy Antibodies  anti-cTn1  >21 publications with cTn1 and Hypertrophy
 Cardiomyopathy, Dilated Antibodies  anti-cTn1  >18 publications with cTn1 and Cardiomyopathy, Dilated
 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7 Antibodies  anti-cTn1  >9 publications with cTn1 and CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7
 Cardiomyopathy, Restrictive Antibodies  anti-cTn1  >7 publications with cTn1 and Cardiomyopathy, Restrictive
 Nervous System Diseases Antibodies  anti-cTn1  >4 publications with cTn1 and Nervous System Diseases
 Cardiomyopathy, Familial Restrictive, 1 Antibodies  anti-cTn1  >3 publications with cTn1 and Cardiomyopathy, Familial Restrictive, 1
Organs/Tissues associated with cTn1 elisa kit
 Organ/Tissue Name  Ref Prod  Pubmed Publications
 Heart Antibodies  cTn1 antibody  >54 publications with cTn1 and Heart
 Embryonic Tissue Antibodies  cTn1 antibody  >2 publications with cTn1 and Embryonic Tissue
 Lung Antibodies  cTn1 antibody  >2 publications with cTn1 and Lung
 Uterus Antibodies  cTn1 antibody  >1 publications with cTn1 and Uterus
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