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Anti-AChR elisa kit :: Acetylcholine Receptor Antibody (AChR) [ELISA Kit]
Catalog #    MBS729942
Unit / Price
48 Strip Wells  /  $545.00 + 1 FREE 8GB USB Flash Drive
96 Strip Wells  /  $800.00 + 1 FREE 8GB USB Flash Drive
    
 Go to:     Product Names    Product Info    Accession #s    Product Desc    Diseases/Tissues/Pathways    Applications    References 
 Product Name    Acetylcholine Receptor Antibody (AChR), ELISA Kit
 Also Known As    Human Anti-Acetylcholine Receptor Antibody (Anti-AChR) ELISA Kit
 Product Synonym Names    Human Anti-Acetylcholine Receptor Antibody (Anti-AChR) ELISA Kit; Anti-Acetylcholine Receptor Antibody (Anti-AChR); Anti-Acetylcholine Receptor Antibody ELISA Kit (Anti-AChR) (Human)
 Product Gene Name    Anti-AChR elisa kit [Similar Products]
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 Anti-AChR elisa kit Manual   
 Chromosome Location    Chromosome: 2; NC_000002.11 (233390870..233401375). Location: 2q37.1
 OMIM    100720
 3D Structure    ModBase 3D Structure for Q07001
 Species Reactivity    Human
 Specificity    This assay has high sensitivity and excellent specificity for detection of ACHRAb. No significant cross-reactivity or interference between ACHRAb and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection between ACHRAb and all the analogues, therefore, cross reaction may still exist in some cases.
 Sensitivity    The sensitivity in this assay is 0.1 ng/mL.
 Preparation and Storage    Store all reagents at 2-8 degree C
 Other Notes for Anti-AChR elisa kit    Small volumes of Anti-AChR elisa kit may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
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 Product Description specifically for Anti-AChR elisa kit    For samples: Serum, plasma, cell culture supernatants, body fluid and tissue homogenate

INTENDED USE This ACHRAb ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Human ACHRAb. This ELISA kit for research use only, not for therapeutic or diagnostic applications!

PRINCIPLE OF THE ASSAY ACHRAb ELISA kit applies the competitive enzyme immunoassay technique utilizing Acetylcholine Receptor antigen and an ACHRAb-HRP conjugate. The assay sample and buffer are incubated together with ACHRAb-HRP conjugate in pre-coated plate for one hour. After the incubation period, the wells are decanted and washed five times. The wells are then incubated with a substrate for HRP enzyme. The product of the enzyme-substrate reaction forms a blue colored complex. Finally, a stop solution is added to stop the reaction, which will then turn the solution yellow. The intensity of color is measured spectrophotometrically at 450nm in a microplate reader. The intensity of the color is inversely proportional to the ACHRAb concentration since ACHRAb from samples and ACHRAb-HRP conjugate compete for the Acetylcholine Receptor antigen binding site. Since the number of sites is limited, as more sites are occupied by ACHRAb from the sample, fewer sites are left to bind ACHRAb-HRP conjugate. A standard curve is plotted relating the intensity of the color (O.D.) to the concentration of standards. The ACHRAb concentration in each sample is interpolated from this standard curve.
 Product Categories/Family for Anti-AChR elisa kit    Human ELISA Kit
NCBI/Uniprot data below describe general gene information for Anti-AChR. It may not necessarily be applicable to this product.
 NCBI GI #    297402 [Other Products]
 NCBI GeneID    1144 [Other Products]
 NCBI Accession #    CAA38759.1 [Other Products]
 UniProt Primary Accession #    Q07001 [Other Products]
 UniProt Secondary Accession #    Q52LH4; A8K661; B4DT92 [Other Products]
 UniProt Related Accession #    Q07001 [Other Products]
 Molecular Weight    58,895 Da
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 NCBI Official Full Name    acetylcholine receptor delta subunit
 NCBI Official Synonym Full Names    cholinergic receptor, nicotinic, delta (muscle)
 NCBI Official Symbol    CHRND [Similar Products]
 NCBI Official Synonym Symbols    ACHRD; CMS2A; FCCMS; SCCMS [Similar Products]
 NCBI Protein Information    acetylcholine receptor subunit delta; acetylcholine receptor, nicotinic, delta (muscle); cholinergic receptor, nicotinic, delta polypeptide
 UniProt Protein Name    Acetylcholine receptor subunit delta
 UniProt Gene Name    CHRND [Similar Products]
 UniProt Synonym Gene Names    ACHRD [Similar Products]
 UniProt Entry Name    ACHD_HUMAN
 NCBI Summary for Anti-AChR    The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in this gene are a cause of multiple pterygium syndrome lethal type (MUPSL), congenital myasthenic syndrome slow-channel type (SCCMS), and congenital myasthenic syndrome fast-channel type (FCCMS). Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Feb 2012]
 UniProt Comments for Anti-AChR    Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subunit structure: Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

Subcellular location: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Involvement in disease: Multiple pterygium syndrome, lethal type (LMPS) [MIM:253290]: Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.11Myasthenic syndrome, congenital, slow-channel (SCCMS) [MIM:601462]: A common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. Congenital myasthenic syndrome slow-channel type is caused by kinetic abnormalities of the AChR, resulting in prolonged endplate currents and prolonged AChR channel opening episodes.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6 Ref.7Myasthenic syndrome, congenital, fast-channel (FCCMS) [MIM:608930]: A congenital myasthenic syndrome characterized by kinetic abnormalities of the AChR. Due in most cases to mutations that decrease activity of the AChR by slowing the rate of opening of the receptor channel, speeding the rate of closure of the channel, or decreasing the number of openings of the channel during ACh occupancy. The result is failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8 Ref.9

Sequence similarities: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-subfamily. [View classification]
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 NCBI References for Anti-AChR    1. Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.
2. A large-scale candidate gene association study of age at menarche and age at natural menopause.
3. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
4. Congenital Myasthenic Syndromes
5. Human variation in alcohol response is influenced by variation in neuronal signaling genes.
 UniProt References for Anti-AChR    • A muscle acetylcholine receptor is expressed in the human cerebellar medulloblastoma cell line TE671. Luther M.A., Schoepfer R., Whiting P., Casey B., Blatt Y., Montal M.S., Montal M., Lindstrom J.J. Neurosci. 9:1082-1096(1989) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Pericardium.
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Heart and Lung.
 Research Articles on Anti-AChR    1. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
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 Searchable Name for Anti-AChR    anti-Anti-AChR; Buy Anti-AChR elisa kit :: Acetylcholine Receptor Antibody (AChR), ELISA Kit (MBS729942) datasheet at MyBioSource; anti-Anti-AChR; ACHRD; CMS2A; FCCMS; SCCMS; ACHRD; anti-Acetylcholine Receptor Antibody (AChR); Human Anti-Acetylcholine Receptor Antibody (Anti-AChR) ELISA Kit; Human Anti-Acetylcholine Receptor Antibody (Anti-AChR) ELISA Kit; Anti-Acetylcholine Receptor Antibody (Anti-AChR); Anti-Acetylcholine Receptor Antibody ELISA Kit (Anti-AChR) (Human); acetylcholine receptor delta subunit; cholinergic receptor, nicotinic, delta (muscle); Acetylcholine receptor subunit delta anti-Human. (NCBI/UniProt 297402 CAA38759.1 Q07001 Q07001 Q52LH4; A8K661; B4DT92 58,895 Da); Human ELISA Kit; Chromosome: 2; NC_000002.11 (233390870..233401375). Location: 2q37.1; 1144; ACHD_HUMAN; Anti-AChR elisa kit; anti-Anti-AChR
 Precautions    This product is for research use only. Not for use in diagnostic or therapeutic procedures.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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Products associated with Anti-AChR elisa kitPathways associated with Anti-AChR elisa kit
 Product Name  Ref Prod  PubMed Publications
 Anti-AChR elisa kit  CHRNA1 elisa kit  >10 publications with Anti-AChR and CHRNA1
 Anti-AChR elisa kit  CHRNB1 elisa kit  >7 publications with Anti-AChR and CHRNB1
 Anti-AChR elisa kit  CHRNE elisa kit  >6 publications with Anti-AChR and CHRNE
 Anti-AChR elisa kit  CHRNA3 elisa kit  >4 publications with Anti-AChR and CHRNA3
 Anti-AChR elisa kit  CHRNA5 elisa kit  >4 publications with Anti-AChR and CHRNA5
 Anti-AChR elisa kit  CHRNB3 elisa kit  >4 publications with Anti-AChR and CHRNB3
 Anti-AChR elisa kit  CHRNA4 elisa kit  >3 publications with Anti-AChR and CHRNA4
 Anti-AChR elisa kit  CHRNA6 elisa kit  >3 publications with Anti-AChR and CHRNA6
 Anti-AChR elisa kit  CHRNA2 elisa kit  >1 publications with Anti-AChR and CHRNA2
 Anti-AChR elisa kit  ALPI elisa kit  >1 publications with Anti-AChR and ALPI
 Product Name  Products by Pathway  Pathway Diagram
 Anti-AChR elisa kit  Acetylcholine Binding And Downstream Events Pathway antibodies  Acetylcholine Binding And Downstream Events Pathway Diagram
 Anti-AChR elisa kit  Activation Of Nicotinic Acetylcholine Receptors Pathway antibodies  Activation Of Nicotinic Acetylcholine Receptors Pathway Diagram
 Anti-AChR elisa kit  Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway antibodies  Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway Diagram
 Anti-AChR elisa kit  Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Anti-AChR elisa kit  Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Anti-AChR elisa kit  Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Anti-AChR elisa kit  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
 Anti-AChR elisa kit  Postsynaptic Nicotinic Acetylcholine Receptors Pathway antibodies  Postsynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
 Anti-AChR elisa kit  Presynaptic Nicotinic Acetylcholine Receptors Pathway antibodies  Presynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
 Anti-AChR elisa kit  Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram
Diseases associated with Anti-AChR elisa kitOrgans/Tissues associated with Anti-AChR elisa kit
 Disease Name  Ref Prod  Pubmed Publications
 Nervous System Diseases Antibodies  anti-Anti-AChR  >10 publications with Anti-AChR and Nervous System Diseases
 MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE Antibodies  anti-Anti-AChR  >4 publications with Anti-AChR and MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE
 Musculoskeletal Abnormalities Antibodies  anti-Anti-AChR  >3 publications with Anti-AChR and Musculoskeletal Abnormalities
 Brain Diseases Antibodies  anti-Anti-AChR  >1 publications with Anti-AChR and Brain Diseases
 Myasthenic Syndrome, Congenital, Fast-Channel Antibodies  anti-Anti-AChR  >1 publications with Anti-AChR and Myasthenic Syndrome, Congenital, Fast-Channel
 Organ/Tissue Name  Ref Prod  Pubmed Publications
 Muscle Antibodies  Anti-AChR antibody  >14 publications with Anti-AChR and Muscle
 Lung Antibodies  Anti-AChR antibody  >1 publications with Anti-AChR and Lung
 Heart Antibodies  Anti-AChR antibody  >1 publications with Anti-AChR and Heart
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