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AChR elisa kit :: Human Acetylcholine Receptor Antibody (AChR) ELISA Kit

Catalog #    MBS729942
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
 
 Go to:     Product Names    Product Info    Accession #s    Product Desc    Diseases/Tissues/Pathways    Applications    References 
 Product Name   

Acetylcholine Receptor Antibody (AChR), ELISA Kit

 Also Known As   

Human Anti-Acetylcholine Receptor Antibody (Anti-AChR) ELISA Kit

 Product Synonym Names    Human Anti-Acetylcholine Receptor Antibody (Anti-AChR) ELISA Kit; Anti-Acetylcholine Receptor Antibody (Anti-AChR); Anti-Acetylcholine Receptor Antibody ELISA Kit (Anti-AChR) (Human)
 Product Gene Name   

AChR elisa kit

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 AChR elisa kit Manual Insert   
 MBS729942 COA   
 MBS729942 MSDS   
 Chromosome Location    Chromosome: 2; NC_000002.11 (233390870..233401375). Location: 2q37.1
 OMIM    100720
 3D Structure    ModBase 3D Structure for Q07001
 Species Reactivity    Human
 Specificity    This assay has high sensitivity and excellent specificity for detection of AchRAb. No significant cross-reactivity or interference between AchRAb and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection between AchRAb and all the analogues, therefore, cross reaction may still exist in some cases.
 Samples    Serum, plasma, cell culture supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Sensitivity    0.1 ng/mL.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact technical support.
 Preparation and Storage    Store all reagents at 2-8 degree C
 Other Notes for AChR elisa kit    Small volumes of AChR elisa kit may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for AChR purchase    anti-AChR cost; Buy AChR elisa kit, Human Acetylcholine Receptor Antibody (AChR) ELISA Kit (MBS729942) product datasheet at MyBioSource, ELISA Kits; Human ELISA Kit; Chromosome: 2; NC_000002.11 (233390870..233401375). Location: 2q37.1; 1144; ACHD_HUMAN; AChR elisa kit price; high sensitivity elisa kit for AChR
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Product Description specifically for AChR elisa kit

   Intended Uses: This AchRAb ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Human AchRAb. This ELISA kit for research use only, not for therapeutic or diagnostic applications!

Principle of the Assay: AchRAb ELISA kit applies the competitive enzyme immunoassay technique utilizing Acetylcholine Receptor antigen and an AchRAb-HRP conjugate. The assay sample and buffer are incubated together with AchRAb-HRP conjugate in pre-coated plate for one hour. After the incubation period, the wells are decanted and washed five times. The wells are then incubated with a substrate for HRP enzyme. The product of the enzyme-substrate reaction forms a blue colored complex. Finally, a stop solution is added to stop the reaction, which will then turn the solution yellow. The intensity of color is measured spectrophotometrically at 450nm in a microplate reader. The intensity of the color is inversely proportional to the AchRAb concentration since AchRAb from samples and AchRAb-HRP conjugate compete for the Acetylcholine Receptor antigen binding site. Since the number of sites is limited, as more sites are occupied by AchRAb from the sample, fewer sites are left to bind AchRAb-HRP conjugate. A standard curve is plotted relating the intensity of the color (O.D.) to the concentration of standards. The AchRAb concentration in each sample is interpolated from this standard curve.
 Product Categories/Family for AChR elisa kit    Human ELISA Kit
 Typical Testing Data/Standard Curve (for reference only) of AChR elisa kit    AChR elisa kit Typical Testing Data/Standard Curve (for reference only) image
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NCBI/Uniprot data below describe general gene information for AChR. It may not necessarily be applicable to this product.
 NCBI GI #    297402
 NCBI GeneID    1144
 NCBI Accession #    CAA38759.1 [Other Products]
 UniProt Primary Accession #    Q07001 [Other Products]
 UniProt Secondary Accession #    Q52LH4; A8K661; B4DT92 [Other Products]
 UniProt Related Accession #    Q07001 [Other Products]
 Molecular Weight    58,895 Da
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 NCBI Official Full Name    acetylcholine receptor delta subunit
 NCBI Official Synonym Full Names    cholinergic receptor, nicotinic, delta (muscle)
 NCBI Official Symbol    CHRND [Similar Products]
 NCBI Official Synonym Symbols   

ACHRD; CMS2A; FCCMS; SCCMS

[Similar Products]
 NCBI Protein Information    acetylcholine receptor subunit delta; acetylcholine receptor, nicotinic, delta (muscle); cholinergic receptor, nicotinic, delta polypeptide
 UniProt Protein Name    Acetylcholine receptor subunit delta
 UniProt Gene Name    CHRND [Similar Products]
 UniProt Synonym Gene Names    ACHRD [Similar Products]
 UniProt Entry Name    ACHD_HUMAN
 NCBI Summary for AChR    The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in this gene are a cause of multiple pterygium syndrome lethal type (MUPSL), congenital myasthenic syndrome slow-channel type (SCCMS), and congenital myasthenic syndrome fast-channel type (FCCMS). Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Feb 2012]
 UniProt Comments for AChR    nAChRD: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in CHRND are a cause of multiple pterygium syndrome lethal type (MUPSL). Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent. Defects in CHRND are a cause of congenital myasthenic syndrome slow-channel type (SCCMS). SCCMS is the most common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. SCCMS is caused by kinetic abnormalities of the AChR, resulting in prolonged endplate currents and prolonged AChR channel opening episodes. Defects in CHRND are a cause of congenital myasthenic syndrome fast-channel type (FCCMS). FCCMS is a congenital myasthenic syndrome characterized by kinetic abnormalities of the AChR. In most cases, FCCMS is due to mutations that decrease activity of the AChR by slowing the rate of opening of the receptor channel, speeding the rate of closure of the channel, or decreasing the number of openings of the channel during ACh occupancy. The result is failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-subfamily.

Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; plasma membrane; cell junction

Molecular Function: nicotinic acetylcholine-activated cation-selective channel activity; acetylcholine binding

Biological Process: skeletal muscle contraction; synaptic transmission; regulation of membrane potential; muscle contraction; transport; neuromuscular process; skeletal muscle growth; signal transduction; musculoskeletal movement

Disease: Myasthenic Syndrome, Congenital, 3a, Slow-channel; Myasthenic Syndrome, Congenital, 3c, Associated With Acetylcholine Receptor Deficiency; Multiple Pterygium Syndrome, Lethal Type; Myasthenic Syndrome, Congenital, 3b, Fast-channel
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 NCBI References for AChR    1. Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.
2. A large-scale candidate gene association study of age at menarche and age at natural menopause.
3. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
4. Congenital Myasthenic Syndromes
5. Human variation in alcohol response is influenced by variation in neuronal signaling genes.
 UniProt References for AChR    • A muscle acetylcholine receptor is expressed in the human cerebellar medulloblastoma cell line TE671. Luther M.A., Schoepfer R., Whiting P., Casey B., Blatt Y., Montal M.S., Montal M., Lindstrom J.J. Neurosci. 9:1082-1096(1989) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Pericardium.
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Heart and Lung.
 Research Articles on AChR    1. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
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 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AChR elisa kitPathways associated with AChR elisa kit
 Reference Product  PubMed Publications
 CHRNA1 elisa kit  >10 publications with AChR and CHRNA1
 CHRNB1 elisa kit  >7 publications with AChR and CHRNB1
 CHRNE elisa kit  >6 publications with AChR and CHRNE
 CHRNA3 elisa kit  >4 publications with AChR and CHRNA3
 CHRNA5 elisa kit  >4 publications with AChR and CHRNA5
 CHRNB3 elisa kit  >4 publications with AChR and CHRNB3
 CHRNA4 elisa kit  >3 publications with AChR and CHRNA4
 CHRNA6 elisa kit  >3 publications with AChR and CHRNA6
 CHRNA2 elisa kit  >1 publications with AChR and CHRNA2
 ALPI elisa kit  >1 publications with AChR and ALPI
 Products by Pathway  Pathway Diagram
 Acetylcholine Binding And Downstream Events Pathway antibodies  Acetylcholine Binding And Downstream Events Pathway Diagram
 Activation Of Nicotinic Acetylcholine Receptors Pathway antibodies  Activation Of Nicotinic Acetylcholine Receptors Pathway Diagram
 Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway antibodies  Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
 Postsynaptic Nicotinic Acetylcholine Receptors Pathway antibodies  Postsynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
 Presynaptic Nicotinic Acetylcholine Receptors Pathway antibodies  Presynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram
Diseases associated with AChR elisa kitOrgans/Tissues associated with AChR elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >10 publications with AChR and Nervous System Diseases
 MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE Antibodies  >4 publications with AChR and MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE
 Musculoskeletal Abnormalities Antibodies  >3 publications with AChR and Musculoskeletal Abnormalities
 Brain Diseases Antibodies  >1 publications with AChR and Brain Diseases
 Myasthenic Syndrome, Congenital, Fast-Channel Antibodies  >1 publications with AChR and Myasthenic Syndrome, Congenital, Fast-Channel
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >14 publications with AChR and Muscle
 Lung Antibodies  >1 publications with AChR and Lung
 Heart Antibodies  >1 publications with AChR and Heart
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