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anti-CYP21A2 antibody :: Rabbit anti-Human Cytochrome P450 21A2 Antibody

Catalog #    MBS856347 anti-CYP21A2 antibody
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:     Product Names    Product Info    Accession #s    Product Desc    Diseases/Tissues/Pathways    Applications    References 
 Product Name   

Cytochrome P450 21A2 (CYP21A2), Antibody

 Also Known As   

Cytochrome P450 21A2 Antibody

 Product Synonym Names    Cytochrome P450 21, EC 1.14.99.10, Cytochrome P450 XXI, Steroid 21-hydroxylase, 21-Ohase, P450-C21, P-450c21, P450-C21B, CYP21, CYP21B, CP21A; Cytochrome P450 21A2 Antibody
 Product Gene Name   

anti-CYP21A2 antibody

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 Immunogen Sequence Length    495
 Chromosome Location    Chromosome: 6; NC_000006.11 (32006093..32009447). Location: 6p21.3
 OMIM    201910
 3D Structure    ModBase 3D Structure for P08686
 Host    Rabbit
 Species Reactivity    Human
 Specificity    Cytochrome P450 21A2 antibody detects endogenous levels of total Cytochrome P450 21A2 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+and Ca2+), pH 7.4, 150mM NaCl,0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human Cytochrome P450 21A2.
 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes for anti-CYP21A2 antibody    Small volumes of anti-CYP21A2 antibody may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
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 Applications Tested/Suitable for anti-CYP21A2 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CYP21A2 antibody    WB: 1:500~1:1000
ELISA: 1:20000
 Western Blot for anti-CYP21A2 antibody    Western blot analysis of extracts from 293 cells, using Cytochrome P450 21A2 antibody.
anti-CYP21A2 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for CYP21A2. It may not necessarily be applicable to this product.
 NCBI GI #    323510663 [Other Products]
 NCBI GeneID    1589 [Other Products]
 NCBI Accession #    NP_000491.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_000500.7 [Other Products]
 UniProt Primary Accession #    P08686 [Other Products]
 UniProt Secondary Accession #    P04033; Q01204; Q08AG8; Q16749; Q16806 [Other Products]
 UniProt Related Accession #    P08686 [Other Products]
 Molecular Weight    55,887 Da [Similar Products]
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 NCBI Official Full Name    steroid 21-hydroxylase isoform a
 NCBI Official Synonym Full Names    cytochrome P450, family 21, subfamily A, polypeptide 2
 NCBI Official Symbol    CYP21A2 [Similar Products]
 NCBI Official Synonym Symbols   

CAH1; CPS1; CA21H; CYP21; CYP21B; P450c21B

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 NCBI Protein Information    steroid 21-hydroxylase; 21-OHase; cytochrome P450 21; cytochrome P450 XXI; cytochrome P450-C21B; steroid 21-monooxygenase; cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2
 UniProt Protein Name    Steroid 21-hydroxylase
 UniProt Synonym Protein Names   

21-OHase; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; Cytochrome P450-C21; Cytochrome P450-C21B

 UniProt Gene Name    CYP21A2 [Similar Products]
 UniProt Synonym Gene Names    CYP21; CYP21B [Similar Products]
 UniProt Entry Name    CP21A_HUMAN
 NCBI Summary for CYP21A2    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
 UniProt Comments for CYP21A2    Function: Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.

Catalytic activity: A steroid + AH2 + O2 = a 21-hydroxysteroid + A + H2O.

Cofactor: Heme group.

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Domain: The leucine-rich hydrophobic amino acid N-terminal region probably helps to anchor the protein to the microsomal membrane.

Polymorphism: Seven non deleterious alleles are known: CYP21A2*1A, CYP21A2*1B, CYP21A2*2, CYP21A2*3, CYP21A2*4, CYP21A2*5 and CYP21A2*6. The sequence shown corresponds to allele CYP21A2*1B. Deleterious alleles are mostly generated by recombinations between CYP21A2 and the pseudogene CYP21A1P through gene conversion. This process consists of recombination events that either delete CYP21A2 or transfer deleterious mutations from CYP21A1P to CYP21A2.

Involvement in disease: Defects in CYP21A2 are the cause of adrenal hyperplasia type 3 (AH3) [

MIM:201910]. AH3 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late onset (NC or LOAH), and 'cryptic' (asymptomatic). Ref.3 Ref.4 Ref.5 Ref.8 Ref.9 Ref.10 Ref.11 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30 Ref.31 Ref.32 Ref.33 Ref.34 Ref.35 Ref.36 Ref.38 Ref.39 Ref.40 Ref.41 Ref.42 Ref.43 Ref.45 Ref.46 Ref.47 Ref.48 Ref.49 Ref.50 Ref.51 Ref.52 Ref.53 Ref.54 Ref.55 Ref.56 Ref.57

Sequence similarities: Belongs to the cytochrome P450 family.
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Product References and Citations specifically for anti-CYP21A2 antibody

   Helmberg A., Mol. Endocrinol. 6:1318-1322(1992).
Collier S., Nat. Genet. 3:260-265(1993).
White P.C., Hum. Mutat. 3:373-378(1994).
 NCBI References for CYP21A2    1. [Characterization of new splicing mutation in steroid 21-hydroxylase gene].
2. Characteristics and prevalence of non-classical congenital adrenal hyperplasia with a V2811 mutation in patients with premature pubarche.
3. Comparison of cAMP-responsive DNA sequences and their binding proteins associated with expression of the bovine CYP17 and CYP11A and human CYP21B genes.
4. [Congenital adrenal hyperplasia due to 21-hydroxylase deficiency--management in adults].
5. Clinical phenotype and mutation spectrum of the CYP21A2 gene in patients with steroid 21-hydroxylase deficiency.
 UniProt References for CYP21A2    • Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: a pseudogene and a genuine gene. Higashi Y., Yoshioka H., Yamane M., Gotoh O., Fujii-Kuriyama Y.Proc. Natl. Acad. Sci. U.S.A. 83:2841-2845(1986) [PubMed: 3486422] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CYP21A2*1A).
• Structure of human steroid 21-hydroxylase genes. White P.C., New M.I., Dupont B.Proc. Natl. Acad. Sci. U.S.A. 83:5111-5115(1986) [PubMed: 3487786] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELE CYP21A2*1B).
• Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia. Rodrigues N.R., Dunham I., Yu C.Y., Carroll M.C., Porter R.R., Campbell R.D.EMBO J. 6:1653-1661(1987) [PubMed: 3038528] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT AH3 THR-268, VARIANTS LEU-9 INS; ARG-102 AND SER-493.
• Nonsense mutation causing steroid 21-hydroxylase deficiency. Globerman H., Amor M., Parker K.L., New M.I., White P.C.J. Clin. Invest. 82:139-144(1988) [PubMed: 3267225] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT AH3 LEU-281, VARIANT LEU-9 INS.
• R339H and P453S: CYP21 mutations associated with nonclassic steroid 21-hydroxylase deficiency that are not apparent gene conversions. Helmberg A., Tusie-Luna M.-T., Tabarelli M., Kofler R., White P.C.Mol. Endocrinol. 6:1318-1322(1992) [PubMed: 1406709] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-9 INS; ARG-102 AND SER-493, VARIANTS AH3 HIS-339 AND SER-453. Tissue: Peripheral blood.
 Research Articles on CYP21A2    1. Authors identified 2 novel CYP21A2 missense mutations (p.H282N and p.Y191H) in 2 Italian patients with simple-virilizing and nonclassic congenital adrenal hyperplasia forms.
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 Searchable Name for CYP21A2    anti-CYP21A2; Buy anti-CYP21A2 antibody ($290), Rabbit anti-Human Cytochrome P450 21A2 Antibody (MBS856347) product datasheet at MyBioSource, Primary Antibodies. Application: Western Blot (WB), ELISA (EIA); Chromosome: 6; NC_000006.11 (32006093..32009447). Location: 6p21.3; 1589; CP21A_HUMAN; anti-CYP21A2 antibody; anti-CYP21A2
 Precautions    This product is for research use only. Not for use in diagnostic or therapeutic procedures.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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Pathways associated with anti-CYP21A2 antibodyDiseases associated with anti-CYP21A2 antibody
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 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >197 publications with CYP21A2 and Hyperplasia
 Adrenal Hyperplasia, Congenital Antibodies  >195 publications with CYP21A2 and Adrenal Hyperplasia, Congenital
 Urogenital Abnormalities Antibodies  >176 publications with CYP21A2 and Urogenital Abnormalities
 Disorders of Sex Development Antibodies  >175 publications with CYP21A2 and Disorders of Sex Development
 Adrenal Gland Diseases Antibodies  >173 publications with CYP21A2 and Adrenal Gland Diseases
 Congenital adrenal hyperplasia due to 21 hydroxylase deficiency Antibodies  >33 publications with CYP21A2 and Congenital adrenal hyperplasia due to 21 hydroxylase deficiency
 Neoplasms Antibodies  >13 publications with CYP21A2 and Neoplasms
 Genital Diseases, Male Antibodies  >8 publications with CYP21A2 and Genital Diseases, Male
 Infertility, Male Antibodies  >7 publications with CYP21A2 and Infertility, Male
 Pregnancy Complications Antibodies  >7 publications with CYP21A2 and Pregnancy Complications
Organs/Tissues associated with anti-CYP21A2 antibody
 Organ/Tissue Name  Pubmed Publications
 Adrenal Gland Antibodies  >27 publications with CYP21A2 and Adrenal Gland
 Liver Antibodies  >6 publications with CYP21A2 and Liver
 Brain Antibodies  >6 publications with CYP21A2 and Brain
 Ovary Antibodies  >5 publications with CYP21A2 and Ovary
 Heart Antibodies  >4 publications with CYP21A2 and Heart
 Muscle Antibodies  >2 publications with CYP21A2 and Muscle
 Eye Antibodies  >1 publications with CYP21A2 and Eye
 Spleen Antibodies  >1 publications with CYP21A2 and Spleen
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