NP_008966.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
keratocan
NCBI Official Synonym Full Names
keratocan
NCBI Protein Information
keratocan
UniProt Protein Name
Keratocan
UniProt Synonym Protein Names
Keratan sulfate proteoglycan keratocan
UniProt Synonym Gene Names
UniProt Entry Name
KERA_HUMAN
NCBI Summary for KERA
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010]
UniProt Comments for KERA
KERA: May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. Defects in KERA are the cause of the autosomal recessive cornea plana 2 (CNA2). In CNA2, the forward convex curvature is flattened, leading to a decrease in refraction, reduced visual activity, extreme hyperopia (usually plus 10 d or more), hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis (often detected at an early age). CNA2 is a rare disorder with a worldwide distribution, but a high prevalence in the Finnish population. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: lysosomal lumen; proteinaceous extracellular matrix; Golgi lumen; extracellular region
Biological Process: keratan sulfate metabolic process; glycosaminoglycan metabolic process; visual perception; keratan sulfate biosynthetic process; carbohydrate metabolic process; response to stimulus; pathogenesis; keratan sulfate catabolic process
Disease: Cornea Plana 2
Product References and Citations for anti-KERA antibody
Aldave, A.J., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4006-4012(2010) Dimasi, D.P., et al. Mol. Vis. 16, 562-569 (2010) : Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) : Melrose, J., et al. Arthritis Res. Ther. 10 (4), R79 (2008) : Liskova, P., et al. Mol. Vis. 13, 1339-1347 (2007) :
Research Articles on KERA
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Products associated with anti-KERA antibody
Pathways associated with anti-KERA antibody
Diseases associated with anti-KERA antibody
Organs/Tissues associated with anti-KERA antibody
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