NP_000757.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cytochrome P450 2A13
NCBI Official Synonym Full Names
cytochrome P450, family 2, subfamily A, polypeptide 13
NCBI Protein Information
cytochrome P450 2A13
UniProt Protein Name
Cytochrome P450 2A13
UniProt Synonym Protein Names
CYPIIA13
UniProt Entry Name
CP2AD_HUMAN
NCBI Summary for CYP2A13
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP2A13
CYP2A5: Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N- dimethylaniline, 2'-methoxyacetophenone, N- nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. Belongs to the cytochrome P450 family.
Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; EC 1.14.14.1; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase; Secondary Metabolites Metabolism - caffeine
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm
Molecular Function: iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen binding
Biological Process: coumarin metabolic process; xenobiotic metabolic process; exogenous drug catabolic process; epoxygenase P450 pathway
Product References and Citations for anti-CYP2A13 antibody
Smith,G., et.al., Xenobiotica 28 (12), 1129-1165 (1998) Nelson,D.R., et.al., Pharmacogenetics 14 (1), 1-18 (2004)
Research Articles on CYP2A13
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Products associated with anti-CYP2A13 antibody
Pathways associated with anti-CYP2A13 antibody
Diseases associated with anti-CYP2A13 antibody
Organs/Tissues associated with anti-CYP2A13 antibody
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