NP_034829.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
36,499 Da
NCBI Official Full Name
L-lactate dehydrogenase A chain isoform 1
NCBI Official Synonym Full Names
lactate dehydrogenase A
NCBI Protein Information
L-lactate dehydrogenase A chain; LDH-M; M-LDH; LDH muscle subunit; lactate dehydrogenase-A; lactate dehydrogenase A4; lactate dehydrogenase 1, A chain
UniProt Protein Name
L-lactate dehydrogenase A chain
UniProt Synonym Protein Names
LDH muscle subunit; LDH-M
UniProt Synonym Gene Names
UniProt Entry Name
LDHA_MOUSE
NCBI Summary for LDHA
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to hemolytic anemia and early postimplantation death in mice. Multiple transcript variants encoding different isoforms have been found for this gene. The mouse genome contains multiple pseudogenes of this gene. [provided by RefSeq, May 2013]
UniProt Comments for LDHA
LDH-A: Homotetramer. Belongs to the LDH/MDH superfamily. LDH family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.1.1.27; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; Apoptosis; Oxidoreductase; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - cysteine and methionine
Cellular Component: membrane; mitochondrion; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; oxidoreductase activity; L-lactate dehydrogenase activity; catalytic activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process: carbohydrate metabolic process; carboxylic acid metabolic process; cellular response to extracellular stimulus; lactate biosynthetic process from pyruvate
Research Articles on LDHA
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Products associated with LDHA elisa kit
Pathways associated with LDHA elisa kit
Diseases associated with LDHA elisa kit
Organs/Tissues associated with LDHA elisa kit
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