NP_932782.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
115,375 Da
NCBI Official Full Name
sn1-specific diacylglycerol lipase alpha
NCBI Official Synonym Full Names
diacylglycerol lipase, alpha
NCBI Official Synonym Symbols
NCBI Protein Information
sn1-specific diacylglycerol lipase alpha; DGL-alpha; neural stem cell-derived dendrite regulator
UniProt Protein Name
Sn1-specific diacylglycerol lipase alpha
UniProt Synonym Protein Names
Neural stem cell-derived dendrite regulator
UniProt Synonym Gene Names
UniProt Entry Name
DGLA_MOUSE
UniProt Comments for DAGLA
NSDDR: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. Defects in DAGLA may be a cause of spinocerebellar ataxia type 20 (SCA20). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA20 is an autosomal dominant, adult- onset form characterized by dysarthria due to spasmodic dysphonia followed by slowly progressive ataxia. A copy number variation consisting of a 260-kb duplication at chromosome 11q12.2-12.3 is responsible for SCA20. The critical gene within the duplicated segment may be DAGLA. Belongs to the AB hydrolase superfamily. Lipase family.
Protein type: Hydrolase; Membrane protein, integral; EC 3.1.1.-; Membrane protein, multi-pass
Cellular Component: membrane; plasma membrane; integral to membrane
Molecular Function: retinyl-palmitate esterase activity; sulfolactone hydrolase activity; 3,4-dihydrocoumarin hydrolase activity; hydrolase activity; metal ion binding; lipase activity; all-trans-retinyl-palmitate hydrolase activity; butyrolactone hydrolase activity; 1-oxa-2-oxocycloheptane lactonase activity; phospholipase activity; prenylcysteine methylesterase activity
Biological Process: neurogenesis; neuroblast proliferation; diacylglycerol catabolic process; arachidonic acid metabolic process; lipid metabolic process; lipid catabolic process; neurotransmitter biosynthetic process
Research Articles on DAGLA
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Pathways associated with DAGLA elisa kit
Diseases associated with DAGLA elisa kit
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