NP_071450.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,115 Da
NCBI Official Full Name
xylosyltransferase 2
NCBI Official Synonym Full Names
xylosyltransferase II
NCBI Official Synonym Symbols
SOS; XT2; XT-II; PXYLT2; xylT-II [Similar Products]
NCBI Protein Information
xylosyltransferase 2
UniProt Protein Name
Xylosyltransferase 2
UniProt Synonym Protein Names
Peptide O-xylosyltransferase 1; Xylosyltransferase II; XT-II; XylT-II
UniProt Synonym Gene Names
UniProt Entry Name
XYLT2_HUMAN
NCBI Summary for XYLT2
The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
UniProt Comments for XYLT2
XYLT2: Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Its enzyme activity has not been demonstrated. Belongs to the glycosyltransferase 14 family. XylT subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Glycan Metabolism - chondroitin sulfate biosynthesis; Membrane protein, integral; EC 2.4.2.26; Glycan Metabolism - heparan sulfate biosynthesis; Transferase
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component: endoplasmic reticulum membrane; Golgi membrane; integral to membrane
Molecular Function: acetylglucosaminyltransferase activity; protein xylosyltransferase activity
Biological Process: chondroitin sulfate biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process; heparin biosynthetic process
Disease: Pseudoxanthoma Elasticum; Spondyloocular Syndrome
Research Articles on XYLT2
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Products associated with XYLT2 elisa kit
Pathways associated with XYLT2 elisa kit
Diseases associated with XYLT2 elisa kit
Organs/Tissues associated with XYLT2 elisa kit
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