NP_001020419.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,748 Da
NCBI Official Full Name
deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 1
NCBI Official Synonym Full Names
deoxyuridine triphosphatase
NCBI Official Synonym Symbols
NCBI Protein Information
deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
UniProt Protein Name
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
UniProt Synonym Protein Names
dUTP pyrophosphatase
UniProt Synonym Gene Names
UniProt Entry Name
DUT_HUMAN
NCBI Summary for DUT
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]
UniProt Comments for DUT
dUTPase: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Belongs to the dUTPase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; EC 3.6.1.23; DNA replication; Mitochondrial; Hydrolase; Nucleotide Metabolism - pyrimidine; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 15q21.1
Cellular Component: nucleoplasm; mitochondrion; nucleus
Molecular Function: protein binding; magnesium ion binding; dUTP diphosphatase activity
Biological Process: dUTP catabolic process; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleoside biosynthetic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; DNA replication; dUMP biosynthetic process
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Products associated with anti-DUT antibody
Pathways associated with anti-DUT antibody
Diseases associated with anti-DUT antibody
Organs/Tissues associated with anti-DUT antibody
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