NP_038476.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
175,385 Da
NCBI Official Full Name
bromodomain adjacent to zinc finger domain protein 1A isoform a
NCBI Official Synonym Full Names
bromodomain adjacent to zinc finger domain, 1A
NCBI Protein Information
bromodomain adjacent to zinc finger domain protein 1A
UniProt Protein Name
Bromodomain adjacent to zinc finger domain protein 1A
UniProt Synonym Protein Names
ATP-dependent chromatin-remodeling protein; ATP-utilizing chromatin assembly and remodeling factor 1; hACF1; CHRAC subunit ACF1; Williams syndrome transcription factor-related chromatin-remodeling factor 180; WCRF180; hWALp1
UniProt Synonym Gene Names
UniProt Entry Name
BAZ1A_HUMAN
NCBI Summary for BAZ1A
The BAZ1A gene encodes the accessory subunit of the ATP-dependent chromatin assembly factor (ACF), a member of the ISWI ('imitation switch') family of chromatin remodeling complexes (summarized by Racki et al., 2009 [PubMed 20033039]).[supplied by OMIM, Apr 2010]
UniProt Comments for BAZ1A
BAZ1A: Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end- positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression. Component of the ACF chromatin remodeling complex that includes BAZ1A and SMARCA5. Additional this complex can form, together with CHRAC1 and POLE1, the histone-fold protein complex, CHRAC. Interacts with NCOR1 (via its RD1 domain); the interaction corepresses a number of NCOR1-regulated genes. Highly expressed in testis and at low or undetectable levels in other tissues analyzed. Belongs to the WAL family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; DNA-binding; DNA replication; ATYPICAL group; BAZ family
Chromosomal Location of Human Ortholog: 14q13.2
Cellular Component: nuclear chromosome; chromatin accessibility complex
Molecular Function: protein binding; histone acetyltransferase activity; zinc ion binding
Biological Process: chromatin remodeling; regulation of transcription, DNA-dependent; transcription, DNA-dependent; DNA-dependent DNA replication
Research Articles on BAZ1A
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Products associated with anti-BAZ1A antibody
Diseases associated with anti-BAZ1A antibody
Organs/Tissues associated with anti-BAZ1A antibody
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