NP_037390.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,030 Da
NCBI Official Full Name
apoptosis-associated speck-like protein containing a CARD isoform a
NCBI Official Synonym Full Names
PYD and CARD domain containing
NCBI Protein Information
apoptosis-associated speck-like protein containing a CARD
UniProt Protein Name
Apoptosis-associated speck-like protein containing a CARD
UniProt Synonym Protein Names
Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1
UniProt Synonym Gene Names
UniProt Entry Name
ASC_HUMAN
NCBI Summary for PYCARD
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PYCARD
PYCARD: Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Forms complexes with other DAPIN domain-containing proteins. Interacts with CIAS1/PYPAF1 and PYDC1. Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U-937, but not in Jurkat T- cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and MOLT-4 lymphocytic leukemia cells. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cell soma; mitochondrion; endoplasmic reticulum; cytoplasm; extracellular region; nucleolus; IkappaB kinase complex; nucleus; cytosol
Molecular Function: protein binding; protein homodimerization activity; protease binding; caspase activator activity; Pyrin domain binding
Biological Process: apoptosis; myeloid dendritic cell activation during immune response; positive regulation of apoptosis; positive regulation of caspase activity; regulation of protein stability; positive regulation of JNK cascade; positive regulation of interleukin-1 beta secretion; signal transduction; defense response to Gram-negative bacterium; positive regulation of activated T cell proliferation; activation of NF-kappaB transcription factor; tumor necrosis factor-mediated signaling pathway; positive regulation of phagocytosis; inflammatory response; defense response to virus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; positive regulation of adaptive immune response; caspase activation; interleukin-1 beta production; positive regulation of interleukin-6 production; negative regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of tumor necrosis factor production; negative regulation of interferon-beta production; myeloid dendritic cell activation; positive regulation of interferon-gamma production; positive regulation of actin filament polymerization; inhibition of NF-kappaB transcription factor; regulation of inflammatory response; innate immune response; regulation of autophagy; positive regulation of transcription factor activity; positive regulation of T cell activation; positive regulation of defense response to virus by host; activation of innate immune response; positive regulation of antigen processing and presentation of peptide antigen via MHC class II
Research Articles on PYCARD
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Products associated with anti-PYCARD antibody
Pathways associated with anti-PYCARD antibody
Diseases associated with anti-PYCARD antibody
Organs/Tissues associated with anti-PYCARD antibody
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