NP_000378.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,944 Da
NCBI Official Full Name
mitochondrial carnitine/acylcarnitine carrier protein
NCBI Official Synonym Full Names
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
NCBI Official Synonym Symbols
NCBI Protein Information
mitochondrial carnitine/acylcarnitine carrier protein
UniProt Protein Name
Mitochondrial carnitine/acylcarnitine carrier protein
UniProt Synonym Protein Names
Carnitine/acylcarnitine translocase; CAC; Solute carrier family 25 member 20
UniProt Synonym Gene Names
UniProt Entry Name
MCAT_HUMAN
NCBI Summary for SLC25A20
This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants. [provided by RefSeq, Jul 2008]
UniProt Comments for SLC25A20
SLC25A20: Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Defects in SLC25A20 are the cause of carnitine- acylcarnitine translocase deficiency (CACT deficiency). It is an autosomal recessive deficiency in mitochondrial oxidation of fatty acids. It is usually lethal within a few hours or days after birth. Symptoms characterizing its normally severe clinical phenotype include fatty hepatomegaly with abnormal liver function, cardiomyopathy, muscle weakness and episodes of life-threatening coma, which eventually lead to death. Belongs to the mitochondrial carrier family.
Protein type: Transporter, SLC family; Membrane protein, integral; Mitochondrial; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: mitochondrion; cytoplasm; mitochondrial inner membrane; integral to membrane
Biological Process: carnitine shuttle; cellular lipid metabolic process
Disease: Carnitine-acylcarnitine Translocase Deficiency
Research Articles on SLC25A20
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Products associated with anti-SLC25A20 antibody
Pathways associated with anti-SLC25A20 antibody
Diseases associated with anti-SLC25A20 antibody
Organs/Tissues associated with anti-SLC25A20 antibody
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