NP_000350.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
89,787 Da
NCBI Official Full Name
protein-glutamine gamma-glutamyltransferase K
NCBI Official Synonym Full Names
transglutaminase 1
NCBI Official Synonym Symbols
LI; KTG; LI1; TGK; ICR2; ARCI1; TGASE [Similar Products]
NCBI Protein Information
protein-glutamine gamma-glutamyltransferase K; TG(K); TGase K; TGase-1; epidermal TGase; transglutaminase K; transglutaminase-1; transglutaminase 1 isoform; transglutaminase, keratinocyte; K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase
UniProt Protein Name
Protein-glutamine gamma-glutamyltransferase K
UniProt Synonym Protein Names
Epidermal TGase; Transglutaminase K; TG(K); TGK; TGase K; Transglutaminase-1; TGase-1
UniProt Synonym Gene Names
UniProt Entry Name
TGM1_HUMAN
NCBI Summary for TGM1
The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]
UniProt Comments for TGM1
TGM1: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. Responsible for cross-linking epidermal proteins during formation of the stratum corneum.
Protein type: Transferase; EC 2.3.2.13
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: cell-cell adherens junction; cornified envelope; intrinsic to membrane
Molecular Function: protein binding; protein-glutamine gamma-glutamyltransferase activity; metal ion binding
Biological Process: keratinocyte differentiation; cell envelope organization and biogenesis; organ morphogenesis; keratinization; protein modification process; peptide cross-linking
Disease: Ichthyosis, Congenital, Autosomal Recessive 1
Research Articles on TGM1
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Diseases associated with TGM1 elisa kit
Organs/Tissues associated with TGM1 elisa kit
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