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SLC25A6 recombinant protein :: ADP/ATP translocase 3 (SLC25A6) [Recombinant Protein]
Catalog #    MBS966254
Unit / Price
1 mg (E Coli Derived)  /  $1,375.00 + 1 FREE 8GB USB Flash Drive
1 mg (Yeast Derived)  /  $1,835.00 + 2 FREE 8GB USB Flash Drive
    
 Go to:     Product Names    Product Info    Accession #s    Product Desc    Diseases/Tissues/Pathways    Applications    References 
 Product Name    ADP/ATP translocase 3 (SLC25A6), Recombinant Protein
 Also Known As    Recombinant Human ADP/ATP translocase 3 (SLC25A6)
 Product Synonym Names    Recombinant ADP/ATP translocase 3 (SLC25A6); ADP/ATP translocase 3; ADP,ATP carrier protein 3 ADP,ATP carrier protein, isoform T2; ANT 2 Adenine nucleotide translocator 3; ANT 3 Solute carrier family 25 member 6
 Product Gene Name    SLC25A6 recombinant protein [Similar Products]
 Product Synonym Gene Name    SLC25A6; ANT3; CDABP0051 [Similar Products]
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 Immunogen Sequence Positions    2-298
 Immunogen Sequence Length    298
 Immunogen Sequence    TEQAISFAKD FLAGGIAAAI SKTAVAPIER VKLLLQVQHA SKQIAADKQY KGIVDCIVRI PKEQGVLSFW RGNLANVIRY FPTQALNFAF KDKYKQIFLG GVDKHTQFWR YFAGNLASGG AAGATSLCFV YPLDFARTRL AADVGKSGTE REFRGLGDCL VKITKSDGIR GLYQGFSVSV QGIIIYRAAY FGVYDTAKGM LPDPKNTHIV VSWMIAQTVT AVAGVVSYPF DTVRRRMMMQ SGRKGADIMY TGTVDCWRKI FRDEGGKAFF KGAWSNVLRG MGGAFVLVLY DELKKVI
 Chromosome Location    Chromosome: Y; NC_000024.9 (1455045..1461039, complement). Location: Xp22.32 and Yp11.3
 OMIM    300151
 3D Structure    ModBase 3D Structure for P12236
 Host    E Coli or Yeast
 Purity/Purification    >90%
 Form/Format    This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
 Tag Information    His tagged
 Species    Homo sapiens (Human)
 Storage Buffer    PBS pH 7.4, 50% glycerol
 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 Other Notes for SLC25A6 recombinant protein    Small volumes of SLC25A6 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
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NCBI/Uniprot data below describe general gene information for SLC25A6. It may not necessarily be applicable to this product.
 NCBI GI #    156071462 [Other Products]
 NCBI GeneID    293 [Other Products]
 NCBI Accession #    NP_001627.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001636.3 [Other Products]
 UniProt Primary Accession #    P12236 [Other Products]
 UniProt Secondary Accession #    Q96C49 [Other Products]
 UniProt Related Accession #    P12236 [Other Products]
 Molecular Weight    32,866 Da [Similar Products]
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 NCBI Official Full Name    ADP/ATP translocase 3
 NCBI Official Synonym Full Names    solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
 NCBI Official Symbol    SLC25A6 [Similar Products]
 NCBI Official Synonym Symbols    AAC3; ANT3; ANT3Y [Similar Products]
 NCBI Protein Information    ADP/ATP translocase 3; ANT 2; ANT 3; ADP,ATP carrier protein 3; ADP/ATP translocator of liver; ADP,ATP carrier protein, liver; adenine nucleotide translocator 3; solute carrier family 25 member 6; ADP,ATP carrier protein, isoform T2
 UniProt Protein Name    ADP/ATP translocase 3
 UniProt Synonym Protein Names    ADP,ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6
 UniProt Gene Name    SLC25A6 [Similar Products]
 UniProt Synonym Gene Names    ANT3; ANT 2; ANT 3 [Similar Products]
 UniProt Entry Name    ADT3_HUMAN
 NCBI Summary for SLC25A6    This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2009]
 UniProt Comments for SLC25A6    Function: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. Ref.6

Subunit structure: Found in a complex with ARL2, ARL2BP and SLC25A6

By similarity. Homodimer. Interacts with influenza A virus PB1-F2 protein and HIV-1 Vpr. Ref.7 Ref.8

Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein. Note: The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria

By similarity.

Miscellaneous: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue

By similarity.The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Sequence similarities: Belongs to the mitochondrial carrier family.Contains 3 Solcar repeats.
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 NCBI References for SLC25A6    1. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation.
2. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs).
3. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
4. Systematic and quantitative assessment of the ubiquitin-modified proteome.
5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 UniProt References for SLC25A6    • DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase. Cozens A.L., Runswick M.J., Walker J.E.J. Mol. Biol. 206:261-280(1989) [PubMed: 2541251] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• Pediatric leukemia cDNA sequencing project. Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-242. Tissue: Leukemia.
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Cervix, Eye and Lung. [4]Bienvenut W.V.Submitted (JUL-2004) to UniProtKBCited for: PROTEIN SEQUENCE OF 2-10, ACETYLATION AT THR-2, MASS SPECTROMETRY. Tissue: B-cell lymphoma.
• Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver. Houldsworth J., Attardi G.Proc. Natl. Acad. Sci. U.S.A. 85:377-381(1988) [PubMed: 2829183] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-298. Tissue: Liver.
 Research Articles on SLC25A6    1. The dynamics of the molecular interactions between the C-terminal region of PB1-F2 protein and VDAC1 and ANT3 were expounded by employing an in silico approach.
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 Searchable Name for SLC25A6    anti-SLC25A6; Buy SLC25A6 recombinant protein :: ADP/ATP translocase 3 (SLC25A6), Recombinant Protein (MBS966254) datasheet at MyBioSource; anti-SLC25A6; SLC25A6; ANT3; CDABP0051 ; AAC3; ANT3; ANT3Y; ANT3; ANT 2; ANT 3; anti-ADP/ATP translocase 3 (SLC25A6); Recombinant Human ADP/ATP translocase 3 (SLC25A6); Recombinant ADP/ATP translocase 3 (SLC25A6); ADP/ATP translocase 3; ADP,ATP carrier protein 3 ADP,ATP carrier protein, isoform T2; ANT 2 Adenine nucleotide translocator 3; ANT 3 Solute carrier family 25 member 6 ; ADP/ATP translocase 3; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6; ADP/ATP translocase 3; ADP,ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6 E Coli or Yeast . (NCBI/UniProt 156071462 NP_001627.2 P12236 NM_001636.3 P12236 Q96C49 32,866 Da); Chromosome: Y; NC_000024.9 (1455045..1461039, complement). Location: Xp22.32 and Yp11.3; 293; ADT3_HUMAN; SLC25A6 recombinant protein; anti-SLC25A6
 Precautions    This product is for research use only. Not for use in diagnostic or therapeutic procedures.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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 Organ/Tissue Name  Ref Prod  Pubmed Publications
 Muscle Antibodies  SLC25A6 antibody  >3 publications with SLC25A6 and Muscle
 Liver Antibodies  SLC25A6 antibody  >2 publications with SLC25A6 and Liver
 Embryonic Tissue Antibodies  SLC25A6 antibody  >2 publications with SLC25A6 and Embryonic Tissue
 Adipose Tissue Antibodies  SLC25A6 antibody  >1 publications with SLC25A6 and Adipose Tissue
 Pituitary Gland Antibodies  SLC25A6 antibody  >1 publications with SLC25A6 and Pituitary Gland
 Connective Tissue Antibodies  SLC25A6 antibody  >1 publications with SLC25A6 and Connective Tissue
 Heart Antibodies  SLC25A6 antibody  >1 publications with SLC25A6 and Heart
 Kidney Antibodies  SLC25A6 antibody  >1 publications with SLC25A6 and Kidney
 Testis Antibodies  SLC25A6 antibody  >1 publications with SLC25A6 and Testis
 Skin Antibodies  SLC25A6 antibody  >1 publications with SLC25A6 and Skin
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