NP_001626.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
76,257 Da
NCBI Official Full Name
amphiphysin isoform 1
NCBI Official Synonym Full Names
amphiphysin
NCBI Official Synonym Symbols
NCBI Protein Information
amphiphysin; amphiphysin I; amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen)
UniProt Protein Name
Amphiphysin
UniProt Synonym Gene Names
UniProt Entry Name
AMPH_HUMAN
NCBI Summary for AMPH
This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Nov 2010]
UniProt Comments for AMPH
amphiphysin: May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 7p14-p13
Cellular Component: synaptic vesicle; synaptic vesicle membrane; cell junction; actin cytoskeleton
Molecular Function: protein binding; phospholipid binding
Biological Process: synaptic transmission; synaptic vesicle endocytosis; endocytosis; learning
Research Articles on AMPH
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Products associated with anti-AMPH antibody
Pathways associated with anti-AMPH antibody
Diseases associated with anti-AMPH antibody
Organs/Tissues associated with anti-AMPH antibody
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