View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List Rabbit BACE (CT) Antibody Catalog # MBS194030 Unit / Price 0.1 mg / $520 +1 FREE 8GB USB 5x0.1 mg / $2,190 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name BACE (CT), Antibody Full Product Name Anti-BACE (CT) Antibody Product Synonym Names Anti-BACE (CT); BACE/Asp2 (CT) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Host Rabbit Specificity Anti-BACE (CT) [Rabbit antibody to peptide corresponding to aa 485-501 at the C-terminus of human BACE.]This antibody recognizes human and mouse BACE (approx. 70 kD). Form/Format 100 ug IgG in 200 ul PBS, pH 7.4, purified by immunoaffinity chromatography. Antigen Peptide corresponding to aa 485- 501 of human BACE. This sequence differs from those of mouse and rat by one amino acid. Stabilizer None Preservatives 0.02% sodium azide. Dilutions Instructions Dilute in PBS or medium which is identical to that used in the assay system. Preparation and Storage This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles. Other Notes Small volumes of anti-BACE (CT) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-BACE (CT) antibody Accumulation of the amyloid- beta peptide (A beta ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. A beta peptide is generated as a result of proteolytic cleavage of the beta -amyloid protein precursor (APP) at beta - and gamma -sites by two proteases. APP is first cleaved by beta - secretase to produce a soluble derivative of the protein and a membrane-anchored 99- amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma -secretase to generate the 4 kD amyloid- beta peptide which is found in brains of patients with Alzheimer's disease. beta -secretase was recently identified and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a transmembrane aspartic protease and colocalizes with APP. Product Categories/Family for anti-BACE (CT) antibody Neuroscience and Signal Transduction Antibodies Applications Tested/Suitable for anti-BACE (CT) antibody Immunoblot Application Notes for anti-BACE (CT) antibody Immunoblotting: use at 1:500-1:1,000 dilution.Positive control: Human brain tissue lysate. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP