NP_001257414.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,386 Da
NCBI Official Full Name
calcium/calmodulin-dependent protein kinase kinase 2 isoform 1
NCBI Official Synonym Full Names
calcium/calmodulin dependent protein kinase kinase 2
NCBI Protein Information
calcium/calmodulin-dependent protein kinase kinase 2
UniProt Protein Name
Calcium/calmodulin-dependent protein kinase kinase 2
UniProt Synonym Protein Names
Calcium/calmodulin-dependent protein kinase kinase beta; CaM-KK beta; CaM-kinase kinase beta; CaMKK beta
UniProt Synonym Gene Names
CAMKKB; KIAA0787; CaM-KK 2; CaM-kinase kinase 2; CaMKK 2; CaM-KK beta; CaM-kinase kinase beta; CaMKK beta [Similar Products]
NCBI Summary for CAMKK2
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
UniProt Comments for CAMKK2
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca2+ signals (). Seems to be involved in hippocampal activation of CREB1 (). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Product References and Citations for anti-CAMKK2 antibody
Hsu L.-S., J. Biol. Chem. 276:31113-31123(2001). Anderson K.A., J. Biol. Chem. 273:31880-31889(1998). Ishikawa Y., FEBS Lett. 550:57-63(2003).
Research Articles on CAMKK2
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Products associated with anti-CAMKK2 antibody
Pathways associated with anti-CAMKK2 antibody
Diseases associated with anti-CAMKK2 antibody
Organs/Tissues associated with anti-CAMKK2 antibody
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