NP_075571.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,275 Da
NCBI Official Full Name
calpain-10 isoform a
NCBI Official Synonym Full Names
calpain 10
NCBI Protein Information
calpain-10
UniProt Protein Name
Calpain-10
UniProt Synonym Protein Names
Calcium-activated neutral proteinase 10; CANP 10
UniProt Synonym Gene Names
NCBI Summary for CAPN10
Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]
UniProt Comments for CAPN10
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.
Product References and Citations for anti-CAPN10 antibody
Horikawa Y., Nat. Genet. 26:163-175(2000). Nagase T., DNA Res. 8:85-95(2001). Ota T., Nat. Genet. 36:40-45(2004).
Research Articles on CAPN10
Precautions
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Pathways associated with anti-CAPN10 antibody
Diseases associated with anti-CAPN10 antibody
Organs/Tissues associated with anti-CAPN10 antibody
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