NP_004349.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
64,987 Da
NCBI Official Full Name
M-phase inducer phosphatase 2 isoform 2
NCBI Official Synonym Full Names
cell division cycle 25B
NCBI Protein Information
M-phase inducer phosphatase 2; dual specificity phosphatase Cdc25B
UniProt Protein Name
M-phase inducer phosphatase 2
UniProt Synonym Protein Names
Dual specificity phosphatase Cdc25B
UniProt Synonym Gene Names
UniProt Entry Name
MPIP2_HUMAN
NCBI Summary for CDC25B
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]
UniProt Comments for CDC25B
CDC25B: a member of the MPI phosphatase family. Activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. Shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. At least four transcript variants for this gene exist. Three splice variant isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; EC 3.1.3.48; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: nucleoplasm; spindle pole; centrosome; cytoplasm; cytosol
Molecular Function: protein binding; protein tyrosine phosphatase activity; protein kinase binding
Biological Process: positive regulation of cytokinesis; mitosis; cell division; positive regulation of protein kinase activity; positive regulation of cell proliferation; mitotic cell cycle; positive regulation of mitotic cell cycle; G2/M transition of mitotic cell cycle; protein amino acid phosphorylation; oocyte maturation; female meiosis I
Research Articles on CDC25B
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Products associated with anti-CDC25B antibody
Pathways associated with anti-CDC25B antibody
Diseases associated with anti-CDC25B antibody
Organs/Tissues associated with anti-CDC25B antibody
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