NP_000758.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,385 Da
NCBI Official Full Name
cytochrome P450 2B6
NCBI Official Synonym Full Names
cytochrome P450 family 2 subfamily B member 6
NCBI Official Synonym Symbols
CPB6; EFVM; IIB1; P450; CYP2B; CYP2B7; CYP2B7P; CYPIIB6 [Similar Products]
NCBI Protein Information
cytochrome P450 2B6
UniProt Protein Name
Cytochrome P450 2B6
UniProt Synonym Protein Names
1,4-cineole 2-exo-monooxygenase; CYPIIB6; Cytochrome P450 IIB1
NCBI Summary for CYP2B6
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP2B6
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Product References and Citations for anti-CYP2B6 antibody
Yamano S., Biochemistry 28:7340-7348(1989). Grimwood J., Nature 428:529-535(2004). Thum T., Lancet 355:979-983(2000).
Research Articles on CYP2B6
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Pathways associated with anti-CYP2B6 antibody
Diseases associated with anti-CYP2B6 antibody
Organs/Tissues associated with anti-CYP2B6 antibody
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