Q14397.6
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Glucokinase regulatory protein
NCBI Official Synonym Full Names
glucokinase (hexokinase 4) regulator
NCBI Official Synonym Symbols
NCBI Protein Information
glucokinase regulatory protein
UniProt Protein Name
Glucokinase regulatory protein
UniProt Synonym Gene Names
UniProt Entry Name
GCKR_HUMAN
NCBI Summary for GCKR
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008]
UniProt Comments for GCKR
GCKR: a key regulator of glucokinase in the liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. When expressed alone, both glucokinase and GCKR localize predominantly to the cytoplasm. Co-expression induces both proteins to localize in the nucleus.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 2p23
Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol
Molecular Function: enzyme inhibitor activity; protein domain specific binding; protein binding; enzyme binding; carbohydrate binding
Biological Process: negative regulation of glucokinase activity; urate metabolic process; protein import into nucleus, translocation; hexose transport; carbohydrate metabolic process; cell glucose homeostasis; pathogenesis; glucose transport; transmembrane transport; response to fructose stimulus; positive regulation of glucokinase activity
Disease: Fasting Plasma Glucose Level Quantitative Trait Locus 5
Research Articles on GCKR
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Products associated with anti-GCKR antibody
Pathways associated with anti-GCKR antibody
Diseases associated with anti-GCKR antibody
Organs/Tissues associated with anti-GCKR antibody
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