NP_000852.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
histamine H1 receptor
NCBI Official Synonym Full Names
histamine receptor H1
NCBI Official Synonym Symbols
NCBI Protein Information
histamine H1 receptor; H1R; HH1R; histamine receptor, subclass H1
UniProt Protein Name
Histamine H1 receptor
UniProt Synonym Gene Names
UniProt Entry Name
HRH1_HUMAN
NCBI Summary for HRH1
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for HRH1
H1R: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3p25
Cellular Component: nucleoplasm; integral to plasma membrane; cytoplasm; plasma membrane
Molecular Function: G-protein coupled receptor activity; histamine receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; inositol phosphate-mediated signaling; positive regulation of vasoconstriction; eosinophil chemotaxis; visual learning; regulation of synaptic plasticity; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of inositol trisphosphate biosynthetic process; regulation of vascular permeability; inflammatory response; memory
Research Articles on HRH1
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Pathways associated with anti-HRH1 antibody
Diseases associated with anti-HRH1 antibody
Organs/Tissues associated with anti-HRH1 antibody
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