NP_001186571.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
adenylate cyclase type 5 isoform 2
NCBI Official Synonym Full Names
adenylate cyclase 5
NCBI Official Synonym Symbols
NCBI Protein Information
adenylate cyclase type 5; adenylyl cyclase 5; adenylate cyclase type V; ATP pyrophosphate-lyase 5
UniProt Protein Name
Adenylate cyclase type 5
UniProt Synonym Protein Names
ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5
UniProt Entry Name
ADCY5_HUMAN
NCBI Summary for ADCY5
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for ADCY5
ADCY5: This is a membrane-bound, calcium-inhibitable adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Nucleotide Metabolism - purine; Lyase; Adenylyl cyclase; Membrane protein, integral; Transporter, aquaporin family; Transporter; EC 4.6.1.1
Chromosomal Location of Human Ortholog: 3q21.1
Cellular Component: integral to membrane; plasma membrane
Molecular Function: protein heterodimerization activity; metal ion binding; ATP binding; adenylate cyclase activity; adenylate cyclase binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; locomotory behavior; signal transduction; G-protein signaling, adenylate cyclase activating pathway; dopamine receptor, adenylate cyclase inhibiting pathway; synaptic transmission; phospholipase C activation; energy reserve metabolic process; renal water homeostasis; innate immune response; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; neuromuscular process controlling balance; adenosine receptor signaling pathway; transmembrane transport; dopamine receptor, adenylate cyclase activating pathway
Disease: Dyskinesia, Familial, With Facial Myokymia
Research Articles on ADCY5
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Products associated with anti-ADCY5 antibody
Pathways associated with anti-ADCY5 antibody
Diseases associated with anti-ADCY5 antibody
Organs/Tissues associated with anti-ADCY5 antibody
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