NP_732115.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Akt1, isoform B
NCBI Official Synonym Symbols
akt; Akt; AKT; Akt/PKB; AKT/PKB; akt1; AKT1; Akt1|PKB; CG4006; D-Akt; dakt; dAkt; dAKT; Dakt; DAkt; dAKT/dPKB; dAkt/PKB; dakt1; dAkt1; dAKT1; Dakt1; DAkt1; DAKT1; DAKT1/PKB; DmelCG4006; dPKB; Dpkb; DPKB; DRAC-PK; DRAC-PK66; DRAC-PK85; l(3)04226; l(3)89Bq; [Similar Products]
NCBI Protein Information
CG4006 gene product from transcript CG4006-RA; Akt kinase; Akt1; Akt1-PA; Akt1-PB; Akt1-PC; CG4006-PA; CG4006-PB; CG4006-PC; dAkt kinase; protein kinase B; related to PKA to PKC protein kinases; related to the A and C kinases
UniProt Protein Name
RAC serine/threonine-protein kinase
UniProt Synonym Protein Names
Akt; Protein kinase B
UniProt Synonym Gene Names
UniProt Entry Name
AKT1_DROME
UniProt Comments for Akt1
Akt1: an oncogenic AGC kinase that plays a critical role in regulating cell survival and metabolism in many different signaling pathways. Dual phosphorylation is required for its activation. T308 is phosphorylated by PDK1 in the PI3 kinase pathway, and S473 is phosphorylated by mTOR in the mTORC2 pathway. The 'Lys-63'-linked ubiquitination of AKT1 by TRAF6 is important for its translocation to the plasma membrane, phosphorylation, and activation. When Akt is fully phosphorylated it translocates into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its proteosomal degradation. Hyperactive or overexpressed in a number of cancers including breast, prostate, lung, pancreatic, liver, ovarian and colorectal. Over 160 protein substrates are known including many that regulate transcription, metabolism, apoptosis, cell cycle, and growth.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Oncoprotein; Protein kinase, AGC; Kinase, protein; AGC group; AKT family
Cellular Component: cell surface; cell soma; cytoplasm; plasma membrane
Molecular Function: protein serine/threonine kinase activity; ATP binding; phosphoinositide binding; protein kinase activity
Biological Process: oogenesis; circadian rhythm; positive regulation of cell size; regulation of dendrite development; chitin-based embryonic cuticle biosynthetic process; positive regulation of multicellular organism growth; protein amino acid phosphorylation; somatic muscle development; regulation of protein import into nucleus; regulation of cell shape; sequestering of lipid; myoblast fusion; negative regulation of synaptic growth at neuromuscular junction; positive regulation of axon regeneration; multicellular organism growth; regulation of multicellular organism growth; regulation of organ growth; positive regulation of cell growth; positive regulation of organ growth; epithelial cell migration, open tracheal system; dendrite regeneration; regulation of hemocyte proliferation; open tracheal system development; insulin receptor signaling pathway; lipid metabolic process; response to oxidative stress; regulation of cell size; negative regulation of apoptosis
Research Articles on Akt1
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Pathways associated with anti-Akt1 antibody
Diseases associated with anti-Akt1 antibody
Organs/Tissues associated with anti-Akt1 antibody
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