NP_001153070
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
NCBI Official Full Name
axin-1 isoform 1
NCBI Official Synonym Full Names
axin 1
NCBI Official Synonym Symbols
Fu; Kb; Ki; Axin; fused; kinky; knobbly; AI316800 [Similar Products]
NCBI Protein Information
axin-1; axis inhibition protein 1; protein Fused
UniProt Protein Name
Axin-1
UniProt Synonym Protein Names
Axis inhibition protein 1; Protein Fused
UniProt Synonym Gene Names
UniProt Entry Name
AXIN1_MOUSE
UniProt Comments for Axin1
axin 1: is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin-1 functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Wild-type axin 1 can induce apoptosis in hepatocellular and colorectal cancer cells. Is downregulated during progression of esophageal squamous cell carcinoma. Mutation of the axin-1 gene is associated with hepatocellular carcinoma, anaplastic thyroid cancer, medulloblastoma and colorectal cancer. May have a role in oncogenesis in Hodgkin lymphoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways.
Protein type: Adaptor/scaffold; Tumor suppressor
Cellular Component: Golgi apparatus; protein complex; cytoplasmic membrane-bound vesicle; postsynaptic density; cell cortex; beta-catenin destruction complex; membrane; cytoplasmic microtubule; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cytoplasmic vesicle; nucleus; lateral plasma membrane
Molecular Function: protein C-terminus binding; identical protein binding; protein domain specific binding; protein homodimerization activity; protein self-association; p53 binding; beta-catenin binding; protein kinase binding; GTPase activator activity; protein binding; signal transducer activity; receptor signaling complex scaffold activity; enzyme binding; ubiquitin protein ligase binding; protein complex scaffold; SMAD binding; receptor binding
Biological Process: cell death; positive regulation of JNK activity; protein polyubiquitination; negative regulation of Wnt receptor signaling pathway; apoptosis; embryonic eye morphogenesis; multicellular organismal development; positive regulation of transcription, DNA-dependent; positive regulation of JNK cascade; negative regulation of protein metabolic process; dorsal/ventral axis specification; nucleocytoplasmic transport; Wnt receptor signaling pathway through beta-catenin; signal transduction; adult walking behavior; olfactory placode formation; activation of JNK activity; cytoplasmic microtubule organization and biogenesis; erythrocyte homeostasis; sensory perception of sound; positive regulation of ubiquitin-protein ligase activity; axial mesoderm development; Wnt receptor signaling pathway involved in forebrain neuron fate commitment; protein catabolic process; protein homooligomerization; axial mesoderm formation; regulation of protein amino acid phosphorylation; Wnt receptor signaling pathway; hemoglobin metabolic process; in utero embryonic development; muscle cell development; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of fat cell differentiation; optic placode formation; neurological system process; cellular protein complex assembly; dorsal/ventral pattern formation; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein kinase activity; forebrain anterior/posterior pattern formation; activation of protein kinase activity; positive regulation of protein catabolic process; positive regulation of protein amino acid phosphorylation; determination of left/right symmetry; positive regulation of GTPase activity
Product References and Citations for anti-Axin1 antibody
Kim S M, et al. (2009) Exp. Cell Res. 315: 943-954 Hsiao-Man Ivy Yu, et al. (2007) Mech Dev, 124(2): 146-156. Liu W, et al. (2006) EMBO J, 25(8):1646-58. Salahshor S, et al. (2005) J Clin Pathol, 58(3):225-36.
Research Articles on Axin1
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Pathways associated with anti-Axin1 antibody
Diseases associated with anti-Axin1 antibody
Organs/Tissues associated with anti-Axin1 antibody
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