NP_004327.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
120,002 Da
NCBI Official Full Name
Homo sapiens BUB1 mitotic checkpoint serine/threonine kinase (BUB1), transcript variant 1, mRNA
NCBI Official Synonym Full Names
BUB1 mitotic checkpoint serine/threonine kinase
NCBI Protein Information
mitotic checkpoint serine/threonine-protein kinase BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog; mitotic spindle checkpoint kinase; putative serine/threonine-protein kinase
UniProt Protein Name
Mitotic checkpoint serine/threonine-protein kinase BUB1
UniProt Synonym Protein Names
BUB1A
UniProt Entry Name
BUB1_HUMAN
NCBI Summary for BUB1
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for BUB1
BUB1: a mitotic-checkpoint protein kinase of the BUB family. Autophosphorylated when the cells enters mitosis. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage. High expression in testis and thymus, less in colon, spleen, lung and small intestine. Expressed in fetal thymus, bone marrow, heart, liver, spleen and thymus. Expression is associated with cells/tissues with a high mitotic index. LOF mutations seen in two colon cancer cell lines exhibiting chromosomal instability, in several leukemias and lymphomas, and in a pancreatic cancer cell line. BUB1 functions in mitotic spindle assembly, and may cause chromosomal instability. In mouse BRCA2 knockouts, mutations in BUB1 and BUBR1 are frequently seen in the resulting tumors. BUB1 and BUBR1 are overexpressed, but not mutated, in many gastric cancers.
Protein type: Cell cycle regulation; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; EC 2.7.11.1; Other group; BUB family
Chromosomal Location of Human Ortholog: 2q14
Cellular Component: nucleoplasm; kinetochore; membrane; cytoplasm; cytosol; condensed nuclear chromosome, pericentric region
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity
Biological Process: mitosis; cell proliferation; viral reproduction; apoptosis; cell division; mitotic cell cycle checkpoint; mitotic cell cycle spindle assembly checkpoint; regulation of chromosome segregation; regulation of sister chromatid cohesion; mitotic cell cycle; protein amino acid phosphorylation; chromosome segregation
Research Articles on BUB1
Precautions
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Products associated with anti-BUB1 antibody
Pathways associated with anti-BUB1 antibody
Diseases associated with anti-BUB1 antibody
Organs/Tissues associated with anti-BUB1 antibody
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