View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-B2M antibody :: Mouse anti-Human Beta 2 Microglobulin Monoclonal Antibody Catalog # MBS311742 Unit / Price 0.1 mg / $440 +1 FREE 8GB USB 5x0.1 mg / $1,785 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Beta 2 Microglobulin (B2M), Monoclonal Antibody Popular Item Full Product Name MAb to Beta 2 Microglobulin Product Synonym Names Monoclonal Antibody to Human Beta 2 Microglobulin Product Gene Name anti-B2M antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Chromosome Location Chromosome: 15; NC_000015.9 (45003685..45010357). Location: 15q21-q22.2 OMIM 109700 3D Structure ModBase 3D Structure for P61769 Clonality Monoclonal Isotype IgG2a Clone Number 236-12301 (B2M-01) Host Mouse Species Reactivity Human Specificity Beta 2 MicroglobulinReacts with beta 2 microglobulin associated with cell-surface MHC Class I molecules and other membrane antigens as well as soluble forms of beta 2 microglobulin. Does not cross react with mouse, bovine, canine, chicken or rabbit. Purity/Purification >95% pure (SDS-PAGE). Ion exchange chromatography and precipitation Form/Format Purified, Liquid Concentration 1 mg/ml (lot specific) Immunogen Purified human beta 2 microglobulin Source Ascites Buffer PBS, pH 7.4 Preservative 15mM Sodium azide Important Note Centrifuge before opening to ensure complete recovery of vial contents. Warnings This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains. Preparation and Storage Store at 2 to 8 degree C ISO Certification Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory. Other Notes Small volumes of anti-B2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Product Categories/Family for anti-B2M antibody Monoclonal Antibodies to Proteins and Bioactive Peptides Applications Tested/Suitable for anti-B2M antibody EIA/ELISA, Flow Cytometry, Immunoprecipitation, Radioimmunoassay, Western Blot TOP NCBI/Uniprot data below describe general gene information for B2M. It may not necessarily be applicable to this product. NCBI GI # 179318 NCBI GeneID 567 NCBI Accession # AAA51811.1 [Other Products] UniProt Primary Accession # P61769 [Other Products] UniProt Secondary Accession # P01884; Q540F8; Q6IAT8; Q9UCK0; Q9UD48; Q9UDF4[Other Products] UniProt Related Accession # P61769; Q16446; Q9UM88[Other Products] TOP NCBI Official Full Name beta-2-microglobulin NCBI Official Synonym Full Names beta-2-microglobulin NCBI Official Symbol B2M [Similar Products] NCBI Official Synonym Symbols B2M [Similar Products] NCBI Protein Information beta-2-microglobulin; OTTHUMP00000161912; beta-2-microglobin; beta chain of MHC class I molecules UniProt Protein Name Beta-2-microglobulin Protein Family Beta-2-microglobulin UniProt Gene Name B2M [Similar Products] UniProt Entry Name B2MG_HUMAN TOP NCBI Summary for B2M This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia. TOP UniProt Comments for B2M Function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.Subunit structure: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Ref.14Subcellular location: Secreted. Note: Detected in serum and urine. Ref.16 Ref.17Post-translational modification: Glycation of Ile-21 is observed in long-term hemodialysis patients.Involvement in disease: Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. Ref.33Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.25 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30 Ref.31 Ref.32Sequence similarities: Belongs to the beta-2-microglobulin family.Contains 1 Ig-like C1-type (immunoglobulin-like) domain. Research Articles on B2M 1. B2M was upregulated in ureteropelvic junction obstruction and decreased after surgical treatment. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-B2M antibody Reference Product PubMed Publications HLA-A antibody >10 publications with B2M and HLA-A HLA-B antibody >8 publications with B2M and HLA-B HLA-G antibody >4 publications with B2M and HLA-G HLA-C antibody >2 publications with B2M and HLA-C HFE antibody >2 publications with B2M and HFE HLA-E antibody >1 publications with B2M and HLA-E FCGRT antibody >1 publications with B2M and FCGRT Pathways associated with anti-B2M antibody Products by Pathway Pathway Diagram Adaptive Immunity Signaling Pathway antibodies Adaptive Immunity Signaling Pathway Diagram Amyloids Pathway antibodies Amyloids Pathway Diagram Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram Antigen Processing And Presentation Pathway antibodies Antigen Processing And Presentation Pathway Diagram Antigen Processing And Presentation Pathway antibodies Antigen Processing And Presentation Pathway Diagram Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram Cytokine Signaling In Immune System Pathway antibodies Cytokine Signaling In Immune System Pathway Diagram Downstream Signaling In Naive CD8+ T Cells Pathway antibodies Downstream Signaling In Naive CD8+ T Cells Pathway Diagram HIV Infection Pathway antibodies HIV Infection Pathway Diagram Host Interactions Of HIV Factors Pathway antibodies Host Interactions Of HIV Factors Pathway Diagram Diseases associated with anti-B2M antibody Disease Name Pubmed Publications Neoplasms Antibodies >148 publications with B2M and Neoplasms Male Urogenital Diseases Antibodies >76 publications with B2M and Male Urogenital Diseases Female Urogenital Diseases Antibodies >71 publications with B2M and Female Urogenital Diseases Cardiovascular Diseases Antibodies >56 publications with B2M and Cardiovascular Diseases Kidney Diseases Antibodies >53 publications with B2M and Kidney Diseases Leukemia Antibodies >42 publications with B2M and Leukemia Lymphoma Antibodies >26 publications with B2M and Lymphoma Renal Insufficiency Antibodies >20 publications with B2M and Renal Insufficiency Inflammation Antibodies >19 publications with B2M and Inflammation HIV Infections Antibodies >16 publications with B2M and HIV Infections Organs/Tissues associated with anti-B2M antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >210 publications with B2M and Blood Kidney Antibodies >78 publications with B2M and Kidney Bone Antibodies >56 publications with B2M and Bone Bone Marrow Antibodies >43 publications with B2M and Bone Marrow Liver Antibodies >30 publications with B2M and Liver Skin Antibodies >22 publications with B2M and Skin Heart Antibodies >19 publications with B2M and Heart Brain Antibodies >18 publications with B2M and Brain Muscle Antibodies >17 publications with B2M and Muscle Spleen Antibodies >14 publications with B2M and Spleen TOP © 2006-24 MyBioSource.com. 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