NP_000751.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
86,609 Da
NCBI Official Full Name
granulocyte colony-stimulating factor receptor isoform a
NCBI Official Synonym Full Names
colony stimulating factor 3 receptor (granulocyte)
NCBI Official Synonym Symbols
NCBI Protein Information
granulocyte colony-stimulating factor receptor; CD114 antigen; G-CSF receptor; G-CSF-R
UniProt Protein Name
Granulocyte colony-stimulating factor receptor
UniProt Synonym Protein Names
CD_antigen: CD114
UniProt Synonym Gene Names
UniProt Entry Name
CSF3R_HUMAN
NCBI Summary for CD114
The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]
UniProt Comments for CD114
GCSFR: the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variant isoforms have been described.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 1p35-p34.3
Cellular Component: integral to plasma membrane; extracellular region
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; receptor activity
Biological Process: neutrophil chemotaxis; cytokine and chemokine mediated signaling pathway; defense response; signal transduction; cell adhesion
Disease: Neutrophilia, Hereditary
Research Articles on CD114
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Products associated with anti-CD114 antibody
Pathways associated with anti-CD114 antibody
Diseases associated with anti-CD114 antibody
Organs/Tissues associated with anti-CD114 antibody
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