NP_008984.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
19,810 Da
NCBI Official Full Name
CD160 antigen
NCBI Official Synonym Full Names
CD160 molecule
NCBI Protein Information
CD160 antigen; CD160-delta Ig; CD160 transmembrane isoform; natural killer cell receptor BY55; natural killer cell receptor, immunoglobulin superfamily member
UniProt Protein Name
CD160 antigen
UniProt Synonym Protein Names
Natural killer cell receptor BY55
UniProt Synonym Gene Names
UniProt Entry Name
BY55_HUMAN
NCBI Summary for CD160
CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]
UniProt Comments for CD160
Function: Receptor showing broad specificity for both classical and non-classical MHC class I molecules. Ref.3
Subunit structure: Homomultimer; disulfide-linked.
Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor.
Tissue specificity: Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to functional NK and T cytotoxic lymphocytes.
Sequence similarities: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Research Articles on CD160
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Pathways associated with anti-CD160 antibody
Diseases associated with anti-CD160 antibody
Organs/Tissues associated with anti-CD160 antibody
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