NP_000725.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
T-cell surface glycoprotein CD3 zeta chain isoform 2
NCBI Official Synonym Full Names
CD247 molecule
NCBI Official Synonym Symbols
T3Z; CD3H; CD3Q; CD3Z; TCRZ; IMD25; CD3-ZETA [Similar Products]
NCBI Protein Information
T-cell surface glycoprotein CD3 zeta chain; CD247 antigen, zeta subunit; CD3Z antigen, zeta polypeptide (TiT3 complex); CD3zeta chain; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor T3 zeta chain; TCR zeta chain
UniProt Protein Name
T-cell surface glycoprotein CD3 zeta chain
UniProt Synonym Protein Names
T-cell receptor T3 zeta chain; CD_antigen: CD247
UniProt Synonym Gene Names
UniProt Entry Name
CD3Z_HUMAN
NCBI Summary for CD247
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CD247
CD3Z: a T cell surface glycoprotein that is a component of the T cell antigen receptor. Plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD3-epsilon results in impaired immune response. Two alternatively spliced isoforms have been described.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q24.2
Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; integral to membrane; alpha-beta T cell receptor complex
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; transmembrane receptor activity
Biological Process: regulation of immune response; viral reproduction; T cell costimulation; innate immune response; T cell receptor signaling pathway; regulation of defense response to virus by virus
Disease: Immunodeficiency 25
Research Articles on CD247
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Products associated with anti-CD247 antibody
Pathways associated with anti-CD247 antibody
Diseases associated with anti-CD247 antibody
Organs/Tissues associated with anti-CD247 antibody
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