NP_001230006.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,186 Da
NCBI Official Full Name
T-cell-specific surface glycoprotein CD28 isoform 2
NCBI Official Synonym Full Names
CD28 molecule
NCBI Official Synonym Symbols
NCBI Protein Information
T-cell-specific surface glycoprotein CD28; CD28 antigen
UniProt Protein Name
T-cell-specific surface glycoprotein CD28
UniProt Synonym Protein Names
TP44; CD_antigen: CD28
UniProt Entry Name
CD28_HUMAN
NCBI Summary for CD28
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
UniProt Comments for CD28
CD28: a type I plasma membrane protein Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Binds to B7-1 and -2. Expressed in T cells and plasma cells, but not in less mature B cells. Six splice-variant isoforms have been described.
Protein type: Membrane protein, integral; Cell surface
Chromosomal Location of Human Ortholog: 2q33
Cellular Component: integral to plasma membrane; plasma membrane; immunological synapse; cytosol; external side of plasma membrane
Molecular Function: identical protein binding; protein binding; protease binding; SH3/SH2 adaptor activity; coreceptor activity
Biological Process: positive regulation of isotype switching to IgG isotypes; viral reproduction; positive regulation of translation; nerve growth factor receptor signaling pathway; positive regulation of interleukin-2 biosynthetic process; cytokine biosynthetic process; T cell receptor signaling pathway; positive regulation of inflammatory response to antigenic stimulus; cell surface receptor linked signal transduction; positive regulation of T cell proliferation; regulatory T cell differentiation; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of viral genome replication; fibroblast growth factor receptor signaling pathway; positive regulation of mitosis; negative thymic T cell selection; humoral immune response; regulation of defense response to virus by virus; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; T cell costimulation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of alpha-beta T cell proliferation
Research Articles on CD28
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Pathways associated with anti-CD28 antibody
Diseases associated with anti-CD28 antibody
Organs/Tissues associated with anti-CD28 antibody
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