EAW61731.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,328 Da
NCBI Official Full Name
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), isoform CRA_c
NCBI Official Synonym Full Names
CD74 molecule, major histocompatibility complex, class II invariant chain
NCBI Protein Information
HLA class II histocompatibility antigen gamma chain
UniProt Protein Name
HLA class II histocompatibility antigen gamma chain
UniProt Synonym Protein Names
HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain; Ii; p33; CD_antigen: CD74
UniProt Synonym Gene Names
UniProt Entry Name
HG2A_HUMAN
NCBI Summary for CD74
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
UniProt Comments for CD74
CD74: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, cytokine; Membrane protein, integral; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: Golgi membrane; multivesicular body; lysosomal lumen; cell surface; membrane; lysosomal membrane; integral to membrane; plasma membrane; trans-Golgi network membrane; vacuole; intracellular; external side of plasma membrane; MHC class II protein complex
Molecular Function: identical protein binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; beta-amyloid binding; cytokine binding; MHC class II protein binding, via antigen binding groove; nitric-oxide synthase binding; MHC class II protein binding
Biological Process: activation of MAPK activity; positive regulation of dendritic cell antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; defense response; prostaglandin biosynthetic process; signal transduction; negative regulation of T cell differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; intracellular protein transport; positive regulation of fibroblast proliferation; negative regulation of mature B cell apoptosis; positive regulation of B cell proliferation; protein complex assembly; positive thymic T cell selection; negative regulation of peptide secretion; positive regulation of T-helper 2 type immune response; chaperone cofactor-dependent protein folding; regulation of macrophage activation; T cell selection; negative thymic T cell selection; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; immunoglobulin mediated immune response; positive regulation of cytokine and chemokine mediated signaling pathway; antigen processing and presentation of endogenous antigen; negative regulation of apoptosis
Product References and Citations for anti-CD74 antibody
6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors; Jiaqiang Caia, Mark Baugha, Darcey Blacka, Clive Longa, D. Jonathan Bennetta, Maureen Dempstera, Xavier Fraderaa, Jonathan Gillespiea, Fiona Andrewsa, Sylviane Boucharensa, John Bruina, Kenneth S. Camerona, Iain Cumminga, William Hamiltona, Philip S. Jonesa, Allard Kapteinb, Emma Kinghorna, Maurice Maidmenta, Iain Martina, Ann Mitchella, Zoran Rankovica, John Robinsona, Paul Sculliona, Joost C.M. Uitdehaagb, Paul Vinkb, Paul Westwooda, Mario van Zeelandb, Leon van Berkomc, Martijn Bastianic, Tommi Meulemansc (Bioorganic & Medicinal Chemistry Letters: Volume: 20 Issue: 15 Page: 4350-4354 DOI: 10.1016/j.bmcl.2010.06.072)
Research Articles on CD74
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Pathways associated with anti-CD74 antibody
Diseases associated with anti-CD74 antibody
Organs/Tissues associated with anti-CD74 antibody
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