NP_001171808.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,025 Da
NCBI Official Full Name
SLAM family member 5 isoform 1
NCBI Official Synonym Full Names
CD84 molecule
NCBI Protein Information
SLAM family member 5; CD84 antigen (leukocyte antigen); cell surface antigen MAX.3; hly9-beta; leucocyte differentiation antigen CD84; leukocyte antigen CD84; leukocyte differentiation antigen CD84; signaling lymphocytic activation molecule 5
UniProt Protein Name
SLAM family member 5
UniProt Synonym Protein Names
Cell surface antigen MAX.3; Hly9-beta; Leukocyte differentiation antigen CD84; Signaling lymphocytic activation molecule 5; CD_antigen: CD84
UniProt Synonym Gene Names
UniProt Entry Name
SLAF5_HUMAN
NCBI Summary for CD84
This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
UniProt Comments for CD84
CD84: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Cell surface; Membrane protein, integral; Immunoglobulin superfamily
Chromosomal Location of Human Ortholog: 1q24
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding; receptor activity
Biological Process: defense response; blood coagulation; homophilic cell adhesion; leukocyte migration
Research Articles on CD84
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Pathways associated with anti-CD84 antibody
Diseases associated with anti-CD84 antibody
Organs/Tissues associated with anti-CD84 antibody
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