NP_001247.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
92,612 Da
NCBI Official Full Name
Homo sapiens cell division cycle 27 (CDC27), transcript variant 2, mRNA
NCBI Official Synonym Full Names
cell division cycle 27
NCBI Official Synonym Symbols
APC3; HNUC; NUC2; H-NUC; ANAPC3; CDC27Hs; D0S1430E; D17S978E [Similar Products]
NCBI Protein Information
cell division cycle protein 27 homolog; anaphase promoting complex subunit 3; anaphase-promoting complex, protein 3; cell division cycle 27 homolog; nuc2 homolog
UniProt Protein Name
Cell division cycle protein 27 homolog
UniProt Synonym Protein Names
Anaphase-promoting complex subunit 3; APC3; CDC27 homolog; CDC27Hs; H-NUC
UniProt Entry Name
CDC27_HUMAN
NCBI Summary for CDC27
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]
UniProt Comments for CDC27
CDC27: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C is composed of at least 12 subunits. Interacts with RB. Interacts with FAM168B/MANI. Belongs to the APC3/CDC27 family.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: nucleoplasm; centrosome; anaphase-promoting complex; spindle microtubule; cytoplasm; spindle; nucleus; cytosol
Molecular Function: protein binding; protein phosphatase binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell proliferation; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle; mitotic metaphase/anaphase transition
Research Articles on CDC27
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Products associated with anti-CDC27 antibody
Pathways associated with anti-CDC27 antibody
Diseases associated with anti-CDC27 antibody
Organs/Tissues associated with anti-CDC27 antibody
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