NP_001139501.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
73,364 Da
NCBI Official Full Name
semaphorin-7A isoform 2 preproprotein
NCBI Official Synonym Full Names
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
NCBI Official Synonym Symbols
JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1 [Similar Products]
NCBI Protein Information
semaphorin-7A; JMH blood group antigen; John Milton Hagen blood group H-Sema K1; john-Milton-Hargen human blood group Ag; sema K1; sema L; sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group); sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A; semaphorin K1; semaphorin L; semaphorin-K1; semaphorin-L
UniProt Protein Name
Semaphorin-7A
UniProt Synonym Protein Names
CDw108; JMH blood group antigen; John-Milton-Hargen human blood group Ag; Semaphorin-K1; Sema K1; Semaphorin-L; Sema L; CD_antigen: CD108
UniProt Synonym Gene Names
UniProt Entry Name
SEM7A_HUMAN
NCBI Summary for CDw108
The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
UniProt Comments for CDw108
SEMA7A: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. Belongs to the semaphorin family.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 15q22.3-q23
Cellular Component: membrane; plasma membrane; external side of plasma membrane
Molecular Function: integrin binding; protein binding; receptor activity
Biological Process: integrin-mediated signaling pathway; osteoblast differentiation; axon guidance; axon extension; positive regulation of axon extension; regulation of inflammatory response; olfactory lobe development; immune response; positive regulation of protein amino acid phosphorylation; inflammatory response
Disease: Blood Group, John Milton Hagen System
Research Articles on CDw108
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Products associated with anti-CDw108 antibody
Pathways associated with anti-CDw108 antibody
Diseases associated with anti-CDw108 antibody
Organs/Tissues associated with anti-CDw108 antibody
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